Further characterization of the B-cell phenotype in ectopic follicle-like structures in the multiple sclerosis brain Magliozzi Roberta ⁎ ,1 , Serafini Barbara 1 , Rosicarelli Barbara 1 , Reynolds Rychard 2 , Aloisi Francesca 1 1 Istituto Superiore di Sanità, Rome, Italy; 2 Imperial College, London, United Kingdom B-cell follicle-like structures have been detected in the postmortem cerebral meninges of approximately 45% of the examined patients with secondary progressive multiple sclerosis (SPMS) and their presence has been associated with more extensive cortical damage and more severe disease clinical course.