In order to investigate the impact of bacterial GelE on the development of chronic intestinal inflammation we monoassociated gnotobiotc wild type (Wt) and Interleukin 10 deficient (IL-10 -/-) mice with GelE expressing E. faecalis strain OG1RF and isogenic mutant strains that lack GelE expression including TX5264 (gelE deletion) and TX5266 (fsrB deletion).