Several regions on PEDV S protein were recognized as containing the neutralizing epitopes, including a CO-26 K equivalent epitope COE (aa 499-638), SS2 (aa 748-755), SS6 (aa 764-771) and 2C10 (aa 1368-1374) (Chang et al., 2002; Ge et al., 2012; Kang et al., 2005; Oszvald et al., 2007) .