S9 ) (Oka et al., 2014) . Although the amino acid sequences of the S proteins of S INDEL strains are closer to the classical strains than to the highly virulent US strains (Fig. 2 ), the rest of the genes (ORF1, ORF3, E, M and N) of S INDEL strains group together with the emerging highly virulent PEDV strains from China, North American, etc. (Figs.