MICs to CAZ, cefotaxime (CTX), cefuroxime (CXM), cefepime (FEP), and amoxicillin-clavulanate (AMX) were determined in MI1443 carrying the different evolved and nonevolved recombinant plasmids. blaCTX-M genes from strains containing recombinant plasmids displaying reduced susceptibility to CAZ were sequenced.