Adverse effects were graded according to the VCOG-CTCAE grading system (grade 1 alopecia, n = 2; grade 1 combined neutropenia and lymphopenia, n = 2; grade 1 lymphopenia, n = 1; grade 1 lethargy, n = 1; grade 2 gastrointestinal signs, n = 1; grade 2 injection site reaction, n = 1; grade 2 hypersensitivity, n = 1; grade 4 hypersensitivity, n = 1; grade 5 hypersensitivity, n = 1).