Objective: Marijuana is a schedule class 1 psychoactive control substance more frequently used by the oriental societies( in the event of jubilation) causing altered state of conscience, euphoria, its prolonged use is followed by addiction and dependence.It contains more than 426 chemical entities with over 60 are of the cannabinoid i.e, cannabidiol (CBD), cannabinol (CBN), and delta-9, tetrahydrocannabinol (THC) The later on use has been associated with craving for further use of narcotics just to enhance the euphorient effects .The active ingredients i.e, Delta-9-TetrahydrocannabinolTHC) and other cannabinoids(THC) are liquid soluble at high concentrations which alters membrane function, resulting in alterations in immune cell response.