[22] [23] [24] Multiple cytokines have been implicated in CRS, including interferon-g, IL-10, and IL-6, and monoclonal antibodies targeting the IL-6/IL-6 receptor axis such as tocilizumab are used for CRS treatment, 24, 25 Marked elevation of serum IL-6 was noted in the case report by Suzuki et al, 19 but to our knowledge, tocilizumab has not been used in the context of bleomycin-associated febrile, hypotensive reactions, and in all cases in the present series, symptoms resolved rapidly following corticosteroid treatment.