CORD-19:16a812de72963ceda960a168236e8dbe91832d45 / 64954-65646 JSONTXT

{"project":"CORD-19-SciBite-sentences","denotations":[{"id":"T745","span":{"begin":0,"end":692},"obj":"http://purl.obolibrary.org/obo/GO0016595"},{"id":"T747","span":{"begin":0,"end":692},"obj":"http://purl.obolibrary.org/obo/GO0032281"},{"id":"T750","span":{"begin":0,"end":692},"obj":"http://purl.obolibrary.org/obo/GO0004308"},{"id":"T753","span":{"begin":0,"end":692},"obj":"http://purl.obolibrary.org/obo/GO0005530"},{"id":"T755","span":{"begin":0,"end":692},"obj":"http://purl.obolibrary.org/obo/GO0005488"}],"attributes":[{"id":"A745","pred":"class","subj":"T745","obj":"GOONTOL"},{"id":"A747","pred":"class","subj":"T747","obj":"GOONTOL"},{"id":"A750","pred":"class","subj":"T750","obj":"GOONTOL"},{"id":"A753","pred":"class","subj":"T753","obj":"GOONTOL"},{"id":"A755","pred":"class","subj":"T755","obj":"GOONTOL"}],"text":"It is interesting to note that AMPA channel function is substantially modified by lectin binding, and concanavalin A binding leads to desensitization of the AMPA channel and a consequent increase in calcium permeability in the absence of changes in glutamate binding (Thalhammer et al., 2002) . Moreover, sialidase treatment modulates AMPA function by alleviating desensitization, and this effect is indirect, as sialic acid residues are not found on the AMPA receptor (Hoffman et al., 1997) . Because NG2 does bear sialic acid residues, it is reasonable to speculate that the effect of deglycosylation or lectin binding is mediated by an alteration in NG2 association with the AMPA receptor."}

{"project":"CORD-19_Custom_license_subset","denotations":[{"id":"T81","span":{"begin":0,"end":294},"obj":"Sentence"},{"id":"T82","span":{"begin":295,"end":493},"obj":"Sentence"},{"id":"T83","span":{"begin":494,"end":692},"obj":"Sentence"}],"text":"It is interesting to note that AMPA channel function is substantially modified by lectin binding, and concanavalin A binding leads to desensitization of the AMPA channel and a consequent increase in calcium permeability in the absence of changes in glutamate binding (Thalhammer et al., 2002) . Moreover, sialidase treatment modulates AMPA function by alleviating desensitization, and this effect is indirect, as sialic acid residues are not found on the AMPA receptor (Hoffman et al., 1997) . Because NG2 does bear sialic acid residues, it is reasonable to speculate that the effect of deglycosylation or lectin binding is mediated by an alteration in NG2 association with the AMPA receptor."}

{"project":"CORD-19-Sentences","denotations":[{"id":"TextSentencer_T323","span":{"begin":0,"end":294},"obj":"Sentence"},{"id":"TextSentencer_T324","span":{"begin":295,"end":493},"obj":"Sentence"},{"id":"TextSentencer_T325","span":{"begin":494,"end":692},"obj":"Sentence"},{"id":"TextSentencer_T323","span":{"begin":0,"end":294},"obj":"Sentence"},{"id":"TextSentencer_T324","span":{"begin":295,"end":493},"obj":"Sentence"},{"id":"TextSentencer_T325","span":{"begin":494,"end":692},"obj":"Sentence"},{"id":"T51747","span":{"begin":0,"end":294},"obj":"Sentence"},{"id":"T81981","span":{"begin":295,"end":493},"obj":"Sentence"},{"id":"T36880","span":{"begin":494,"end":692},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"It is interesting to note that AMPA channel function is substantially modified by lectin binding, and concanavalin A binding leads to desensitization of the AMPA channel and a consequent increase in calcium permeability in the absence of changes in glutamate binding (Thalhammer et al., 2002) . Moreover, sialidase treatment modulates AMPA function by alleviating desensitization, and this effect is indirect, as sialic acid residues are not found on the AMPA receptor (Hoffman et al., 1997) . Because NG2 does bear sialic acid residues, it is reasonable to speculate that the effect of deglycosylation or lectin binding is mediated by an alteration in NG2 association with the AMPA receptor."}

{"project":"Epistemic_Statements","denotations":[{"id":"T137","span":{"begin":0,"end":294},"obj":"Epistemic_statement"},{"id":"T138","span":{"begin":494,"end":692},"obj":"Epistemic_statement"}],"text":"It is interesting to note that AMPA channel function is substantially modified by lectin binding, and concanavalin A binding leads to desensitization of the AMPA channel and a consequent increase in calcium permeability in the absence of changes in glutamate binding (Thalhammer et al., 2002) . Moreover, sialidase treatment modulates AMPA function by alleviating desensitization, and this effect is indirect, as sialic acid residues are not found on the AMPA receptor (Hoffman et al., 1997) . Because NG2 does bear sialic acid residues, it is reasonable to speculate that the effect of deglycosylation or lectin binding is mediated by an alteration in NG2 association with the AMPA receptor."}