CORD-19:16a812de72963ceda960a168236e8dbe91832d45 / 56776-57704 JSONTXT

{"project":"CORD-19-SciBite-sentences","denotations":[{"id":"T642","span":{"begin":0,"end":928},"obj":"http://purl.obolibrary.org/obo/GO0005886"},{"id":"T643","span":{"begin":0,"end":928},"obj":"http://purl.obolibrary.org/obo/GO0045121"},{"id":"T644","span":{"begin":0,"end":928},"obj":"http://purl.obolibrary.org/obo/GO0007165"},{"id":"T646","span":{"begin":0,"end":928},"obj":"http://purl.obolibrary.org/obo/GO0019722"}],"attributes":[{"id":"A642","pred":"class","subj":"T642","obj":"GOONTOL"},{"id":"A643","pred":"class","subj":"T643","obj":"GOONTOL"},{"id":"A644","pred":"class","subj":"T644","obj":"GOONTOL"},{"id":"A646","pred":"class","subj":"T646","obj":"GOONTOL"}],"text":"Another important clue as to the mechanism of remyelination-promoting antibody action was provided by experiments showing that the ability of rHIgM22 to induce calcium influx and rescue CG4 cells from death was dependent on the integrity of lipid rafts in the plasma membrane of these cells (Howe et al., 2004) . Treatment with β-methylcyclodextrin, a cholesterol-chelating compound that effectively destroys lipid raft structure, prevented rHIgM22-induced survival signaling, suggesting that perhaps redistribution or aggregation of lipid raft domains is necessary for antibody-mediated signal transduction (Howe et al., 2004) (Fig. 20) . This hypothesis is further supported by evidence that monovalent forms of sHIgM22 are unable to elicit remyelination or calcium signaling , suggesting that multivalency, and therefore oligomerization of cognate antigen, is necessary for the function of remyelination-promoting antibodies."}

{"project":"CORD-19_Custom_license_subset","denotations":[{"id":"T43","span":{"begin":0,"end":312},"obj":"Sentence"},{"id":"T44","span":{"begin":313,"end":639},"obj":"Sentence"},{"id":"T45","span":{"begin":640,"end":928},"obj":"Sentence"}],"text":"Another important clue as to the mechanism of remyelination-promoting antibody action was provided by experiments showing that the ability of rHIgM22 to induce calcium influx and rescue CG4 cells from death was dependent on the integrity of lipid rafts in the plasma membrane of these cells (Howe et al., 2004) . Treatment with β-methylcyclodextrin, a cholesterol-chelating compound that effectively destroys lipid raft structure, prevented rHIgM22-induced survival signaling, suggesting that perhaps redistribution or aggregation of lipid raft domains is necessary for antibody-mediated signal transduction (Howe et al., 2004) (Fig. 20) . This hypothesis is further supported by evidence that monovalent forms of sHIgM22 are unable to elicit remyelination or calcium signaling , suggesting that multivalency, and therefore oligomerization of cognate antigen, is necessary for the function of remyelination-promoting antibodies."}

{"project":"CORD-19-Sentences","denotations":[{"id":"TextSentencer_T285","span":{"begin":0,"end":312},"obj":"Sentence"},{"id":"TextSentencer_T286","span":{"begin":313,"end":639},"obj":"Sentence"},{"id":"TextSentencer_T287","span":{"begin":640,"end":928},"obj":"Sentence"},{"id":"TextSentencer_T285","span":{"begin":0,"end":312},"obj":"Sentence"},{"id":"TextSentencer_T286","span":{"begin":313,"end":639},"obj":"Sentence"},{"id":"TextSentencer_T287","span":{"begin":640,"end":928},"obj":"Sentence"},{"id":"T97413","span":{"begin":0,"end":312},"obj":"Sentence"},{"id":"T85652","span":{"begin":313,"end":639},"obj":"Sentence"},{"id":"T33435","span":{"begin":640,"end":928},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Another important clue as to the mechanism of remyelination-promoting antibody action was provided by experiments showing that the ability of rHIgM22 to induce calcium influx and rescue CG4 cells from death was dependent on the integrity of lipid rafts in the plasma membrane of these cells (Howe et al., 2004) . Treatment with β-methylcyclodextrin, a cholesterol-chelating compound that effectively destroys lipid raft structure, prevented rHIgM22-induced survival signaling, suggesting that perhaps redistribution or aggregation of lipid raft domains is necessary for antibody-mediated signal transduction (Howe et al., 2004) (Fig. 20) . This hypothesis is further supported by evidence that monovalent forms of sHIgM22 are unable to elicit remyelination or calcium signaling , suggesting that multivalency, and therefore oligomerization of cognate antigen, is necessary for the function of remyelination-promoting antibodies."}

{"project":"Epistemic_Statements","denotations":[{"id":"T126","span":{"begin":313,"end":633},"obj":"Epistemic_statement"},{"id":"T127","span":{"begin":640,"end":928},"obj":"Epistemic_statement"}],"text":"Another important clue as to the mechanism of remyelination-promoting antibody action was provided by experiments showing that the ability of rHIgM22 to induce calcium influx and rescue CG4 cells from death was dependent on the integrity of lipid rafts in the plasma membrane of these cells (Howe et al., 2004) . Treatment with β-methylcyclodextrin, a cholesterol-chelating compound that effectively destroys lipid raft structure, prevented rHIgM22-induced survival signaling, suggesting that perhaps redistribution or aggregation of lipid raft domains is necessary for antibody-mediated signal transduction (Howe et al., 2004) (Fig. 20) . This hypothesis is further supported by evidence that monovalent forms of sHIgM22 are unable to elicit remyelination or calcium signaling , suggesting that multivalency, and therefore oligomerization of cognate antigen, is necessary for the function of remyelination-promoting antibodies."}

{"project":"CORD-19-PD-MONDO","denotations":[{"id":"T182","span":{"begin":86,"end":89},"obj":"Disease"},{"id":"T183","span":{"begin":207,"end":210},"obj":"Disease"}],"attributes":[{"id":"A182","pred":"mondo_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/MONDO_0010518"},{"id":"A183","pred":"mondo_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/MONDO_0010518"}],"text":"Another important clue as to the mechanism of remyelination-promoting antibody action was provided by experiments showing that the ability of rHIgM22 to induce calcium influx and rescue CG4 cells from death was dependent on the integrity of lipid rafts in the plasma membrane of these cells (Howe et al., 2004) . Treatment with β-methylcyclodextrin, a cholesterol-chelating compound that effectively destroys lipid raft structure, prevented rHIgM22-induced survival signaling, suggesting that perhaps redistribution or aggregation of lipid raft domains is necessary for antibody-mediated signal transduction (Howe et al., 2004) (Fig. 20) . This hypothesis is further supported by evidence that monovalent forms of sHIgM22 are unable to elicit remyelination or calcium signaling , suggesting that multivalency, and therefore oligomerization of cognate antigen, is necessary for the function of remyelination-promoting antibodies."}