More viral RNA was detected in the brain and spinal cord of IFNγ −/− H-2 q mice as compared to IFNγ +/− H-2 q or IFNγ +/+ H-2 q mice at 14 and 21 days after TMEV infection, and virus antigen was localized predominantly to spinal motor neurons in infected IFNγ −/− H-2 q mice.