CORD-19:16a812de72963ceda960a168236e8dbe91832d45 / 20886-22549
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/CORD-19/sourceid/16a812de72963ceda960a168236e8dbe91832d45","sourcedb":"CORD-19","sourceid":"16a812de72963ceda960a168236e8dbe91832d45","text":"For example, disruption of MHC class I function by deletion of β 2 -microglobulin in SJL/J mice results in more demyelination and increased neurological deficit (Begolka et al., 2001) , and in the SJL/J strain it has been suggested that MHC class II-restricted T-cell response (Miller et al., 1987) , and epitope-spreading to myelin antigens may be the mechanism of demyelination and neurological deficit (Croxford et al., 2002; Miller et al., 1997) . However, CD8 + MHC class I-restricted cytotoxic T-cells have definitely been implicated in human MS, and it is likely that demyelination and neurological dysfunction in humans are a combination of both CD8 + -and CD4 + -mediated mechanisms (Neumann, 2003) . Recent pathological studies have shown that CD8 + T-cells may be the most common subset of T-cells in the MS brain and appear to be clonally expanded in MS lesions (Babbe et al., 2000) . Recent experiments in collaboration with Hans Lassmann have demonstrated intense expression of MHC class I in oligodendrocytes, neurons, axons, and astrocytes in the MS lesion (Hoftberger et al., 2003) , and autopsy studies have demonstrated that CD8 + T-cells are statistically associated with axonal injury in MS (Bitsch et al., 2000) . In addition, CD8 + T-cells have been shown to injure neurons and transect axons in vitro (Medana et al., 2000 (Medana et al., , 2001 , and imaging studies have indicated that axonal loss in MS is a direct correlate for disability (Narayanan et al., 1997; Truyen et al., 1996; van Waesberghe et al., 1999) . These studies suggest that CD8 + T-cells may be the primary effectors for axonal injury and neurological deficits in 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