The implications of this finding are also relevant to understanding evolutionary processes in other viruses such as Hepatitis C virus (Kim et al, 2003) , Dengue virus (Alvarez et al, 2005) , Flock house virus (Lindenbach et al, 2002) and Barley yellow dwarf virus (Miller and White, 2006) , all of which contain functional long-distance RNA-RNA interactions involving coding regions.