Development of ARDS varied with the codon 54 genotype (p < .05), with patients who were homozygous for the variant codon 54B allele having an increased odds of developing ARDS compared with homozygotes or heterozygotes for the wild-type A allele (odds ratio [OR], 5.0, 95% confidence interval [CI], 1.3-20; p = .02) (Fig. 3) .