The proportion with IgA antibodies to HCoV-NL63 in nasal wash specimens of patients with a history of heart disease was higher than that of patients without heart disease (6 [16%] versus 2 [3%]; P ϭ 0.014), but the proportions with IgA antibodies to the other three HCoV strains in nasal wash specimens from patients with and those without heart disease did not differ (data not shown).