CD28-B7, ICOS-ICOSL, and CD2-LFA-3 typify co-stimulatory molecules of the Ig superfamily (120, 121), whereas TNFR/TNF family members are typified by, but are not exclusive to, OX40-OX40L; 4-1BB-4-1BBL; CD27-CD70; GITR-GITRL; CD30-CD30L and HVEM-LIGHT (114, (122) (123) (124) .