CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection

Abstract
Graphical Abstract Highlights d Deficiency of CARMA3 results in the host resistance to RNA viral infection d CARMA3 positively regulates RIG-I/MAVS-mediated NF-kB activation d CARMA3 negatively regulates RIG-I/MAVS-mediated TBK1/ IRF3 activation d CARMA3 negatively suppresses MAVS oligomerization in mitochondran SUMMARY Host response to RNA virus infection is sensed by RNA sensors such as RIG-I, which induces MAVSmediated NF-kB and IRF3 activation to promote inflammatory and antiviral responses, respec