CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection Abstract Graphical Abstract Highlights d Deficiency of CARMA3 results in the host resistance to RNA viral infection d CARMA3 positively regulates RIG-I/MAVS-mediated NF-kB activation d CARMA3 negatively regulates RIG-I/MAVS-mediated TBK1/