J o u r n a l P r e -p r o o f (Bai, et al., 2016; Bixler, et al., 2018; Jacobs, et al., 2015; Oestereich, Ludtke, et al., 2014; Sissoko, et al., 2016; Smither, et al., 2014) Severe fever with thrombocytopenia syndrome (SFTS) caused by a virus infection 12-30% b (Gowen, Westover, Miao, et al., 2017a; Tani, et al., 2016; Yasukawa, 2016) Severe influenza (Cao, 2018; Wang et al., 2019) Lassa virus infection 1% a , severe cases 15% a (Gowen, Westover, Sefing, et al., 2017b; Mendenhall, et al., 2011; Oestereich, et al., 2016; Raabe, et al., 2017; Safronetz, et al., 2015) Rabies Approximately 100% a, b (Baker, 2017; Yamada, Noguchi, Komeno, Furuta, & Nishizono, 2015) Norovirus infection 50,000 deaths/year b (Arias, Thorne, & Goodfellow, 2014; Ruis, et al., 2018) Avian influenza A(H5N1) 52.8% (Sep 9, 2019) a Favipiravir is effective against influenza in animals and humans and has J o u r n a l P r e -p r o o f