Although the physiological role of ACE2 ectodomain shedding remains elusive as roles for circulating ACE2 and remnant Cterminal domain have yet to be identified, shedding seems to be involved in SARS-CoV cellular entry and replication and an ADAM17 inhibitor suppresses SARS-CoV replication in vitro (Glowacka et al., 2010; Haga et al., 2008) .