PMC:329117 (9) JSONTXT < > 5 Projects
Our study has provided an olfactory receptor cDNA resource representing over one-third of the olfactory receptor gene family. We have thus established over 400 annotated olfactory receptor genes as having olfactory function. The sequences we generated demonstrate that the majority of the olfactory receptor gene family has multiple transcriptional isoforms. Most olfactory receptor transcripts encode functional receptor proteins, with rare exceptions. We show that individual olfactory receptor genes can have vastly different expression levels, an intriguing finding in light of the unusual one-neuron one-gene transcriptional regime of the olfactory epithelium. Our results and the sequences we provide will facilitate future global studies of the mechanisms and dynamics of olfactory receptor gene expression.
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