PubMed:6159744 JSONTXT

[Neuropeptides in regulation]. Neuropeptide in der Regulation. 1. The thyroid gland is regulated on nerval and neurohormonal way by the hypothalamus, in which case the hypothalamus is regarded as one of the most important limbs in the chain of the limbic system. 2. The thyreotropin releasing hormone, a tripeptide, is characterized in its double function as releaser and as neuroregulator. As a releaser it controls the function of the thyroid gland by releasing the thyroid gland stimulating hormone of the pituitary gland and by guaranteeing the adaptation to various functional conditions through the thyroid hormones (T3 and T4). As a neuroregulator the thyroid gland stimulating hormone is able to stimulate irritation conditions, muscle tension, increase of temperature and the modification of the effect of neuropharmaca. Apart from this its antipsychotic and antidepressive effect is well-known. 3. The peptide character of such releasing hormones allows to conclude that these and their analoga may perform similar double functions. As instance for a neuroregulator investigations with substance P at the model of the neurotic hypertension and the spontaneous hypertension of the rat are cited and it is shown that this peptide or an SP-analogon may correct hyper- as well as hyporeactive changes in the regulation. Thus for the first time for substance P a universal normalising function could be demonstrated. 4. As a possible mechanism the principle of effectiveness of the probability and improbability relation is discussed and demonstrated in a simple model of representation.