Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-56 |
Sentence |
denotes |
Olfactory vector hypothesis for encephalitis lethargica. |
T2 |
57-209 |
Sentence |
denotes |
Viruses have long been implicated in the pathogenesis of classical encephalitis lethargica, which was first described by Constantin von Economo in 1917. |
T3 |
210-615 |
Sentence |
denotes |
In this article, I propose the hypothesis that an airborne virus travels along the olfactory conduit to infect the olfactory bulb; this local infection or induced neuroinflammation, in turn, retrogradely targets certain neuronal populations with sleep-wake regulatory functions in the hypothalamus and midbrain, leading to the development of wakeful inactivity, a hallmark clinical feature of the disease. |
T4 |
616-844 |
Sentence |
denotes |
Furthermore, the olfactory vector hypothesis may also explain the pathomechanism of the debilitating complication of the disease, i.e., postencephalitic parkinsonism, in terms of a recently discovered nigro-olfactory projection. |
T1 |
0-56 |
Sentence |
denotes |
Olfactory vector hypothesis for encephalitis lethargica. |
T2 |
57-209 |
Sentence |
denotes |
Viruses have long been implicated in the pathogenesis of classical encephalitis lethargica, which was first described by Constantin von Economo in 1917. |
T3 |
210-615 |
Sentence |
denotes |
In this article, I propose the hypothesis that an airborne virus travels along the olfactory conduit to infect the olfactory bulb; this local infection or induced neuroinflammation, in turn, retrogradely targets certain neuronal populations with sleep-wake regulatory functions in the hypothalamus and midbrain, leading to the development of wakeful inactivity, a hallmark clinical feature of the disease. |
T4 |
616-844 |
Sentence |
denotes |
Furthermore, the olfactory vector hypothesis may also explain the pathomechanism of the debilitating complication of the disease, i.e., postencephalitic parkinsonism, in terms of a recently discovered nigro-olfactory projection. |