PubMed:2611779 JSONTXT

{"project":"GlyCosmos6-UBERON","denotations":[{"id":"T1","span":{"begin":420,"end":425},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0003655"}],"text":"Lactonization of GD1b ganglioside under acidic conditions.\nGangliosides that contain the disialosyl residue alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2--3)- can lactonize in the presence of traces of acid and this reaction has been studied in detail on GD1b [beta-Gal-(1--3)-beta-GalNAc-(1 --4)-[alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2 --3)]-beta-Gal-(1--4)-beta-Glc-1--1)-Cer]. Lactonization occurs rapidly at a proton-ganglioside molar ratio of less than 1. At equilibrium, the ratio of GD1b to its lactone is 3:7. The data suggest the possibility that a proton-driven lactonization of gangliosides may occur in vivo."}

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T1","span":{"begin":17,"end":21},"obj":"Glycan_Motif"},{"id":"T3","span":{"begin":114,"end":120},"obj":"Glycan_Motif"},{"id":"T4","span":{"begin":134,"end":140},"obj":"Glycan_Motif"},{"id":"T5","span":{"begin":245,"end":249},"obj":"Glycan_Motif"},{"id":"T7","span":{"begin":294,"end":300},"obj":"Glycan_Motif"},{"id":"T8","span":{"begin":314,"end":320},"obj":"Glycan_Motif"},{"id":"T9","span":{"begin":477,"end":481},"obj":"Glycan_Motif"}],"attributes":[{"id":"A1","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G97612UN"},{"id":"A2","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G37184KW"},{"id":"A3","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY"},{"id":"A4","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY"},{"id":"A5","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G97612UN"},{"id":"A6","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G37184KW"},{"id":"A7","pred":"image","subj":"T7","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY"},{"id":"A8","pred":"image","subj":"T8","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY"},{"id":"A9","pred":"image","subj":"T9","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G97612UN"},{"id":"A10","pred":"image","subj":"T9","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G37184KW"}],"text":"Lactonization of GD1b ganglioside under acidic conditions.\nGangliosides that contain the disialosyl residue alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2--3)- can lactonize in the presence of traces of acid and this reaction has been studied in detail on GD1b [beta-Gal-(1--3)-beta-GalNAc-(1 --4)-[alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2 --3)]-beta-Gal-(1--4)-beta-Glc-1--1)-Cer]. Lactonization occurs rapidly at a proton-ganglioside molar ratio of less than 1. At equilibrium, the ratio of GD1b to its lactone is 3:7. The data suggest the possibility that a proton-driven lactonization of gangliosides may occur in vivo."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":58},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":59,"end":366},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":367,"end":447},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":448,"end":504},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":505,"end":607},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":58},"obj":"Sentence"},{"id":"T2","span":{"begin":59,"end":366},"obj":"Sentence"},{"id":"T3","span":{"begin":367,"end":447},"obj":"Sentence"},{"id":"T4","span":{"begin":448,"end":504},"obj":"Sentence"},{"id":"T5","span":{"begin":505,"end":607},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Lactonization of GD1b ganglioside under acidic conditions.\nGangliosides that contain the disialosyl residue alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2--3)- can lactonize in the presence of traces of acid and this reaction has been studied in detail on GD1b [beta-Gal-(1--3)-beta-GalNAc-(1 --4)-[alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2 --3)]-beta-Gal-(1--4)-beta-Glc-1--1)-Cer]. Lactonization occurs rapidly at a proton-ganglioside molar ratio of less than 1. At equilibrium, the ratio of GD1b to its lactone is 3:7. The data suggest the possibility that a proton-driven lactonization of gangliosides may occur in vivo."}

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":17,"end":21},"obj":"https://glytoucan.org/Structures/Glycans/G37184KW"},{"id":"T2","span":{"begin":17,"end":21},"obj":"https://glytoucan.org/Structures/Glycans/G97612UN"},{"id":"T3","span":{"begin":114,"end":120},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T4","span":{"begin":134,"end":140},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T5","span":{"begin":245,"end":249},"obj":"https://glytoucan.org/Structures/Glycans/G37184KW"},{"id":"T6","span":{"begin":245,"end":249},"obj":"https://glytoucan.org/Structures/Glycans/G97612UN"},{"id":"T7","span":{"begin":294,"end":300},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T8","span":{"begin":314,"end":320},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T9","span":{"begin":477,"end":481},"obj":"https://glytoucan.org/Structures/Glycans/G37184KW"},{"id":"T10","span":{"begin":477,"end":481},"obj":"https://glytoucan.org/Structures/Glycans/G97612UN"}],"text":"Lactonization of GD1b ganglioside under acidic conditions.\nGangliosides that contain the disialosyl residue alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2--3)- can lactonize in the presence of traces of acid and this reaction has been studied in detail on GD1b [beta-Gal-(1--3)-beta-GalNAc-(1 --4)-[alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2 --3)]-beta-Gal-(1--4)-beta-Glc-1--1)-Cer]. Lactonization occurs rapidly at a proton-ganglioside molar ratio of less than 1. At equilibrium, the ratio of GD1b to its lactone is 3:7. The data suggest the possibility that a proton-driven lactonization of gangliosides may occur in vivo."}

{"project":"Glycosmos6-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":17,"end":21},"obj":"http://www.glycoepitope.jp/epitopes/EP0059"},{"id":"T2","span":{"begin":245,"end":249},"obj":"http://www.glycoepitope.jp/epitopes/EP0059"},{"id":"T3","span":{"begin":477,"end":481},"obj":"http://www.glycoepitope.jp/epitopes/EP0059"}],"text":"Lactonization of GD1b ganglioside under acidic conditions.\nGangliosides that contain the disialosyl residue alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2--3)- can lactonize in the presence of traces of acid and this reaction has been studied in detail on GD1b [beta-Gal-(1--3)-beta-GalNAc-(1 --4)-[alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2 --3)]-beta-Gal-(1--4)-beta-Glc-1--1)-Cer]. Lactonization occurs rapidly at a proton-ganglioside molar ratio of less than 1. At equilibrium, the ratio of GD1b to its lactone is 3:7. The data suggest the possibility that a proton-driven lactonization of gangliosides may occur in vivo."}