PubMed:21486442 JSONTXT

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{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/21486442","sourcedb":"PubMed","sourceid":"21486442","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/21486442","text":"Evaluating the impact of Relative Total Dose Intensity (RTDI) on patients' short and long-term outcome in taxane- and anthracycline-based chemotherapy of metastatic breast cancer- a pooled analysis.\nBACKGROUND: Chemotherapy dose delay and/or reduction lower relative total dose intensity (RTDI) and may affect short- and long-term outcome of metastatic breast cancer (MBC) patients.\nMETHODS: Based on 933 individual patients' data of from 3 randomized MBC trials using an anthracycline and taxane we examined the impact of RTDI on efficacy and determined the lowest optimal RTDI for MBC patients.\nRESULTS: Median time to disease progression (TTDP) and overall survival (OS) of all patients were 39 and 98 weeks. Overall higher RTDI was correlated with a shorter TTDP (log-rank p = 0.0525 for 85% RTDI cut-off). Proportional hazards assumption was violated, there was an early drop in the TTDP-curve for the high RTDI group. It was explained by the fact that patients with primary disease progression (PDP) do have a high RTDI per definition. Excluding those 114 patients with PDP the negative correlation between RTDI and TTDP vanished. However, non-PDP patients with RTDI-cut-off levels \u003c85% showed a shorter OS than patients with higher RTDI levels (p = 0.0086).\nCONCLUSIONS: Optimizing RTDI above 85% appears to improve long-term outcome of MBC patients receiving first-line chemotherapy. Lowering RTDI had no negative influence on short term outcome like OR and TTDP.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":353,"end":366},"obj":"HP_0003002"},{"id":"T2","span":{"begin":353,"end":366},"obj":"HP_0100013"},{"id":"T3","span":{"begin":360,"end":366},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"}]},{"project":"Allie","denotations":[{"id":"SS1_21486442_0_0","span":{"begin":25,"end":54},"obj":"expanded"},{"id":"SS2_21486442_0_0","span":{"begin":56,"end":60},"obj":"abbr"},{"id":"SS1_21486442_2_0","span":{"begin":258,"end":287},"obj":"expanded"},{"id":"SS2_21486442_2_0","span":{"begin":289,"end":293},"obj":"abbr"},{"id":"SS1_21486442_2_1","span":{"begin":342,"end":366},"obj":"expanded"},{"id":"SS2_21486442_2_1","span":{"begin":368,"end":371},"obj":"abbr"},{"id":"SS1_21486442_6_0","span":{"begin":613,"end":640},"obj":"expanded"},{"id":"SS2_21486442_6_0","span":{"begin":642,"end":646},"obj":"abbr"},{"id":"SS1_21486442_6_1","span":{"begin":652,"end":668},"obj":"expanded"},{"id":"SS2_21486442_6_1","span":{"begin":670,"end":672},"obj":"abbr"},{"id":"SS1_21486442_9_0","span":{"begin":972,"end":999},"obj":"expanded"},{"id":"SS2_21486442_9_0","span":{"begin":1001,"end":1004},"obj":"abbr"}],"relations":[{"id":"AE1_21486442_0_0","pred":"abbreviatedTo","subj":"SS1_21486442_0_0","obj":"SS2_21486442_0_0"},{"id":"AE1_21486442_2_0","pred":"abbreviatedTo","subj":"SS1_21486442_2_0","obj":"SS2_21486442_2_0"},{"id":"AE1_21486442_2_1","pred":"abbreviatedTo","subj":"SS1_21486442_2_1","obj":"SS2_21486442_2_1"},{"id":"AE1_21486442_6_0","pred":"abbreviatedTo","subj":"SS1_21486442_6_0","obj":"SS2_21486442_6_0"},{"id":"AE1_21486442_6_1","pred":"abbreviatedTo","subj":"SS1_21486442_6_1","obj":"SS2_21486442_6_1"},{"id":"AE1_21486442_9_0","pred":"abbreviatedTo","subj":"SS1_21486442_9_0","obj":"SS2_21486442_9_0"}],"attributes":[{"subj":"SS1_21486442_0_0","pred":"source","obj":"Allie"},{"subj":"SS2_21486442_0_0","pred":"source","obj":"Allie"},{"subj":"SS1_21486442_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_21486442_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_21486442_2_1","pred":"source","obj":"Allie"},{"subj":"SS2_21486442_2_1","pred":"source","obj":"Allie"},{"subj":"SS1_21486442_6_0","pred":"source","obj":"Allie"},{"subj":"SS2_21486442_6_0","pred":"source","obj":"Allie"},{"subj":"SS1_21486442_6_1","pred":"source","obj":"Allie"},{"subj":"SS2_21486442_6_1","pred":"source","obj":"Allie"},{"subj":"SS1_21486442_9_0","pred":"source","obj":"Allie"},{"subj":"SS2_21486442_9_0","pred":"source","obj":"Allie"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#93e9ec","default":true},{"id":"Allie","color":"#ecd493"}]}]}}