Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-131 |
Sentence |
denotes |
Post-translational and transcriptional regulation of glycolipid glycosyltransferase genes in apoptotic breast carcinoma cells: VII. |
TextSentencer_T2 |
132-186 |
Sentence |
denotes |
Studied by DNA-microarray after treatment with L-PPMP. |
TextSentencer_T3 |
187-331 |
Sentence |
denotes |
Functions of glycosphingolipids on the eukaryotic cell membranes during the onset of oncogenic processes and cell death are not well understood. |
TextSentencer_T4 |
332-576 |
Sentence |
denotes |
Inhibitors of glycosphingolipid biosynthesis were recently found to trigger apoptosis in many carcinoma including breast cancer SKBR-3, MCF-7, and MDA-468 cells through either intrinsic or extrinsic apoptotic pathways as we previously reported. |
TextSentencer_T5 |
577-708 |
Sentence |
denotes |
These anti-cancer inhibitors could increase ceramide concentration by blocking functions of glycolipid glycosyltransferases (GLTs). |
TextSentencer_T6 |
709-868 |
Sentence |
denotes |
In this study, using a novel fluorescent dye (ASK-0) revealed the damage of cell organelle membranes by an inhibitor of glucosylceramide biosynthesis (L-PPMP). |
TextSentencer_T7 |
869-1023 |
Sentence |
denotes |
A highly drug- and cell-dependent regulation of MAPKs was also found by cis-platin and L-PPMP when inducing apoptosis in SKBR-3, MCF-7, and MDA-468 cells. |
TextSentencer_T8 |
1024-1134 |
Sentence |
denotes |
A dose and time-dependent regulation of GLTs were investigated by enzymatic assay and DNA microarray analyses. |
TextSentencer_T9 |
1135-1257 |
Sentence |
denotes |
These GLTs are involved in biosynthesis of Le(X) and sialosyl-Le(X) (neolactosyl-ceramide series) such as GalT-4 (UDP-Gal: |
TextSentencer_T10 |
1258-1409 |
Sentence |
denotes |
LcOse3cer beta-galactosyltransferase, GalT-5 (UDP-Gal: nLcOse4Cer alpha1, 3galactosyltransferase, FucT-3 (GDP-Fucose: LM1 alpha1, 4fucosyltransferase). |
TextSentencer_T11 |
1410-1535 |
Sentence |
denotes |
A similar effect was observed with the GLTs involved in the biosyntheses of Gg-series gangliosides, such as SAT-4 (CMP-NeuAc: |
TextSentencer_T12 |
1536-1628 |
Sentence |
denotes |
GgOse4Cer alpha2, 3sialyltransferase, and SAT-2 (CMP-NeuAc: GM3 alpha2, 8sialyltransferase). |
TextSentencer_T13 |
1629-1858 |
Sentence |
denotes |
The glycol-related gene DNA-microarrays also suggested the transcriptional regulation of several GLTs involved in the biosynthesis of neolactosylceramide containing cell-surface antigens in these apoptotic breast carcinoma cells. |
TextSentencer_T14 |
1859-2034 |
Sentence |
denotes |
In the early apoptotic stages (2 to 6 h after L-PPMP treatment) in addition to GlcT-1 gene, several genes (betaGalTs and betaGlcNAcTs) in the SA-Le(a) pathway were stimulated. |
T1 |
0-131 |
Sentence |
denotes |
Post-translational and transcriptional regulation of glycolipid glycosyltransferase genes in apoptotic breast carcinoma cells: VII. |
T2 |
132-186 |
Sentence |
denotes |
Studied by DNA-microarray after treatment with L-PPMP. |
T3 |
187-331 |
Sentence |
denotes |
Functions of glycosphingolipids on the eukaryotic cell membranes during the onset of oncogenic processes and cell death are not well understood. |
T4 |
332-576 |
Sentence |
denotes |
Inhibitors of glycosphingolipid biosynthesis were recently found to trigger apoptosis in many carcinoma including breast cancer SKBR-3, MCF-7, and MDA-468 cells through either intrinsic or extrinsic apoptotic pathways as we previously reported. |
T5 |
577-708 |
Sentence |
denotes |
These anti-cancer inhibitors could increase ceramide concentration by blocking functions of glycolipid glycosyltransferases (GLTs). |
T6 |
709-868 |
Sentence |
denotes |
In this study, using a novel fluorescent dye (ASK-0) revealed the damage of cell organelle membranes by an inhibitor of glucosylceramide biosynthesis (L-PPMP). |
T7 |
869-1023 |
Sentence |
denotes |
A highly drug- and cell-dependent regulation of MAPKs was also found by cis-platin and L-PPMP when inducing apoptosis in SKBR-3, MCF-7, and MDA-468 cells. |
T8 |
1024-1134 |
Sentence |
denotes |
A dose and time-dependent regulation of GLTs were investigated by enzymatic assay and DNA microarray analyses. |
T9 |
1135-1257 |
Sentence |
denotes |
These GLTs are involved in biosynthesis of Le(X) and sialosyl-Le(X) (neolactosyl-ceramide series) such as GalT-4 (UDP-Gal: |
T10 |
1258-1409 |
Sentence |
denotes |
LcOse3cer beta-galactosyltransferase, GalT-5 (UDP-Gal: nLcOse4Cer alpha1, 3galactosyltransferase, FucT-3 (GDP-Fucose: LM1 alpha1, 4fucosyltransferase). |
T11 |
1410-1535 |
Sentence |
denotes |
A similar effect was observed with the GLTs involved in the biosyntheses of Gg-series gangliosides, such as SAT-4 (CMP-NeuAc: |
T12 |
1536-1628 |
Sentence |
denotes |
GgOse4Cer alpha2, 3sialyltransferase, and SAT-2 (CMP-NeuAc: GM3 alpha2, 8sialyltransferase). |
T13 |
1629-1858 |
Sentence |
denotes |
The glycol-related gene DNA-microarrays also suggested the transcriptional regulation of several GLTs involved in the biosynthesis of neolactosylceramide containing cell-surface antigens in these apoptotic breast carcinoma cells. |
T14 |
1859-2034 |
Sentence |
denotes |
In the early apoptotic stages (2 to 6 h after L-PPMP treatment) in addition to GlcT-1 gene, several genes (betaGalTs and betaGlcNAcTs) in the SA-Le(a) pathway were stimulated. |