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PubMed:19184418 JSONTXT

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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 103-109 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 226-241 Body_part denotes eukaryotic cell http://purl.obolibrary.org/obo/CL_0000255
T3 242-251 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T6 282-291 Body_part denotes processes http://purl.obolibrary.org/obo/UBERON_0004529
T7 296-300 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T8 446-452 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T9 785-789 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T10 790-809 Body_part denotes organelle membranes http://purl.obolibrary.org/obo/GO_0031090
T11 888-892 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T12 1794-1798 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T13 1799-1806 Body_part denotes surface http://purl.obolibrary.org/obo/UBERON_0002416
T14 1835-1841 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 829-845 Glycan_Motif denotes glucosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G71142DF
T2 1178-1183 Glycan_Motif denotes Le(X) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC
T3 1197-1202 Glycan_Motif denotes Le(X) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC
T4 1368-1374 Glycan_Motif denotes Fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO
T5 1596-1599 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T7 2004-2009 Glycan_Motif denotes Le(a) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-131 Sentence denotes Post-translational and transcriptional regulation of glycolipid glycosyltransferase genes in apoptotic breast carcinoma cells: VII.
TextSentencer_T2 132-186 Sentence denotes Studied by DNA-microarray after treatment with L-PPMP.
TextSentencer_T3 187-331 Sentence denotes Functions of glycosphingolipids on the eukaryotic cell membranes during the onset of oncogenic processes and cell death are not well understood.
TextSentencer_T4 332-576 Sentence denotes Inhibitors of glycosphingolipid biosynthesis were recently found to trigger apoptosis in many carcinoma including breast cancer SKBR-3, MCF-7, and MDA-468 cells through either intrinsic or extrinsic apoptotic pathways as we previously reported.
TextSentencer_T5 577-708 Sentence denotes These anti-cancer inhibitors could increase ceramide concentration by blocking functions of glycolipid glycosyltransferases (GLTs).
TextSentencer_T6 709-868 Sentence denotes In this study, using a novel fluorescent dye (ASK-0) revealed the damage of cell organelle membranes by an inhibitor of glucosylceramide biosynthesis (L-PPMP).
TextSentencer_T7 869-1023 Sentence denotes A highly drug- and cell-dependent regulation of MAPKs was also found by cis-platin and L-PPMP when inducing apoptosis in SKBR-3, MCF-7, and MDA-468 cells.
TextSentencer_T8 1024-1134 Sentence denotes A dose and time-dependent regulation of GLTs were investigated by enzymatic assay and DNA microarray analyses.
TextSentencer_T9 1135-1257 Sentence denotes These GLTs are involved in biosynthesis of Le(X) and sialosyl-Le(X) (neolactosyl-ceramide series) such as GalT-4 (UDP-Gal:
TextSentencer_T10 1258-1409 Sentence denotes LcOse3cer beta-galactosyltransferase, GalT-5 (UDP-Gal: nLcOse4Cer alpha1, 3galactosyltransferase, FucT-3 (GDP-Fucose: LM1 alpha1, 4fucosyltransferase).
TextSentencer_T11 1410-1535 Sentence denotes A similar effect was observed with the GLTs involved in the biosyntheses of Gg-series gangliosides, such as SAT-4 (CMP-NeuAc:
TextSentencer_T12 1536-1628 Sentence denotes GgOse4Cer alpha2, 3sialyltransferase, and SAT-2 (CMP-NeuAc: GM3 alpha2, 8sialyltransferase).
TextSentencer_T13 1629-1858 Sentence denotes The glycol-related gene DNA-microarrays also suggested the transcriptional regulation of several GLTs involved in the biosynthesis of neolactosylceramide containing cell-surface antigens in these apoptotic breast carcinoma cells.
TextSentencer_T14 1859-2034 Sentence denotes In the early apoptotic stages (2 to 6 h after L-PPMP treatment) in addition to GlcT-1 gene, several genes (betaGalTs and betaGlcNAcTs) in the SA-Le(a) pathway were stimulated.
T1 0-131 Sentence denotes Post-translational and transcriptional regulation of glycolipid glycosyltransferase genes in apoptotic breast carcinoma cells: VII.
T2 132-186 Sentence denotes Studied by DNA-microarray after treatment with L-PPMP.
T3 187-331 Sentence denotes Functions of glycosphingolipids on the eukaryotic cell membranes during the onset of oncogenic processes and cell death are not well understood.
T4 332-576 Sentence denotes Inhibitors of glycosphingolipid biosynthesis were recently found to trigger apoptosis in many carcinoma including breast cancer SKBR-3, MCF-7, and MDA-468 cells through either intrinsic or extrinsic apoptotic pathways as we previously reported.
T5 577-708 Sentence denotes These anti-cancer inhibitors could increase ceramide concentration by blocking functions of glycolipid glycosyltransferases (GLTs).
T6 709-868 Sentence denotes In this study, using a novel fluorescent dye (ASK-0) revealed the damage of cell organelle membranes by an inhibitor of glucosylceramide biosynthesis (L-PPMP).
T7 869-1023 Sentence denotes A highly drug- and cell-dependent regulation of MAPKs was also found by cis-platin and L-PPMP when inducing apoptosis in SKBR-3, MCF-7, and MDA-468 cells.
T8 1024-1134 Sentence denotes A dose and time-dependent regulation of GLTs were investigated by enzymatic assay and DNA microarray analyses.
T9 1135-1257 Sentence denotes These GLTs are involved in biosynthesis of Le(X) and sialosyl-Le(X) (neolactosyl-ceramide series) such as GalT-4 (UDP-Gal:
T10 1258-1409 Sentence denotes LcOse3cer beta-galactosyltransferase, GalT-5 (UDP-Gal: nLcOse4Cer alpha1, 3galactosyltransferase, FucT-3 (GDP-Fucose: LM1 alpha1, 4fucosyltransferase).
T11 1410-1535 Sentence denotes A similar effect was observed with the GLTs involved in the biosyntheses of Gg-series gangliosides, such as SAT-4 (CMP-NeuAc:
T12 1536-1628 Sentence denotes GgOse4Cer alpha2, 3sialyltransferase, and SAT-2 (CMP-NeuAc: GM3 alpha2, 8sialyltransferase).
T13 1629-1858 Sentence denotes The glycol-related gene DNA-microarrays also suggested the transcriptional regulation of several GLTs involved in the biosynthesis of neolactosylceramide containing cell-surface antigens in these apoptotic breast carcinoma cells.
T14 1859-2034 Sentence denotes In the early apoptotic stages (2 to 6 h after L-PPMP treatment) in addition to GlcT-1 gene, several genes (betaGalTs and betaGlcNAcTs) in the SA-Le(a) pathway were stimulated.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 829-845 https://glytoucan.org/Structures/Glycans/G71142DF denotes glucosylceramide
T2 1178-1183 https://glytoucan.org/Structures/Glycans/G01187XC denotes Le(X)
T3 1197-1202 https://glytoucan.org/Structures/Glycans/G01187XC denotes Le(X)
T4 1368-1374 https://glytoucan.org/Structures/Glycans/G82576YO denotes Fucose
T5 1596-1599 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 1596-1599 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 2004-2009 https://glytoucan.org/Structures/Glycans/G00047MO denotes Le(a)

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 120-125 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 237-241 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 296-300 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 460-466 http://purl.obolibrary.org/obo/CLO_0052102 denotes SKBR-3
T5 468-473 http://purl.obolibrary.org/obo/CLO_0050868 denotes MCF-7
T6 487-492 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 785-789 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8 888-892 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9 990-996 http://purl.obolibrary.org/obo/CLO_0052102 denotes SKBR-3
T10 998-1003 http://purl.obolibrary.org/obo/CLO_0050868 denotes MCF-7
T11 1017-1022 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12 1376-1379 http://purl.obolibrary.org/obo/CLO_0007338 denotes LM1
T13 1486-1488 http://purl.obolibrary.org/obo/CLO_0003417 denotes Gg
T14 1794-1798 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T15 1852-1857 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 103-119 Disease denotes breast carcinoma http://purl.obolibrary.org/obo/MONDO_0004989
T2 426-435 Disease denotes carcinoma http://purl.obolibrary.org/obo/MONDO_0004993
T3 446-459 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T4 588-594 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T5 1835-1851 Disease denotes breast carcinoma http://purl.obolibrary.org/obo/MONDO_0004989

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 468-471 OrganismTaxon denotes MCF NCBItxid:11785
T2 998-1001 OrganismTaxon denotes MCF NCBItxid:11785