PubMed:17592300 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/17592300","sourcedb":"PubMed","sourceid":"17592300","text":"Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.\nOBJECTIVE: To examine the association of single nucleotide polymorphisms (SNPs) in inflammation-related genes in the development of infections following esophagectomy.\nSUMMARY BACKGROUND DATA: Genetic polymorphisms for immunoregulatory cytokines may explain individual variation in response to trauma. Esophagectomy is associated with a high risk of postoperative infection and sepsis, and this study explored a number of SNPs in cytokine genes and their relationship to postoperative infection.\nMETHODS: : In a prospective analysis of 197 patients with esophageal cancer undergoing resection, 55 developed postoperative infections. DNA was extracted and genotyping was performed for polymorphisms in genes encoding TNF-alpha, IL-1beta, IL-1 receptor antagonist, IL-10, and Toll-like receptor 4 (TLR-4) using Taqman chemistry and PCR/RFLP. In a blinded analysis, the cohort with infections was compared with the no complication cohort (n = 114) and a cohort that had noninfective complications (n = 28).\nRESULTS: No differences in polymorphisms for IL-1beta, IL-1 RN, IL-10, and TLR-4 genes were observed across groups. The frequency of TNF-alpha -308 GG homozygotes was significantly (P = 0.021) higher in the postoperative infection group. The G allele was significantly higher in the postoperative infection group compared with the no complication group (P = 0.017) and other complication group (P = 0.013). By multivariate analysis, this polymorphism as well as age and body mass index were predictors of infection.\nCONCLUSION: The TNF-alpha -308A allele has been shown to be associated with higher circulating levels of TNF-alpha and the -308 G allele is a comparative low secretor allele. We propose that the polymorphism in the promotor region of TNF-alpha gene may lead to altered expression and a possible suboptimal activity of TNF-alpha in persons with GG genotypes, and these data suggest a link with infection following major surgery.","tracks":[{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":128},"obj":"Sentence"},{"id":"T2","span":{"begin":129,"end":139},"obj":"Sentence"},{"id":"T3","span":{"begin":140,"end":296},"obj":"Sentence"},{"id":"T4","span":{"begin":297,"end":321},"obj":"Sentence"},{"id":"T5","span":{"begin":322,"end":430},"obj":"Sentence"},{"id":"T6","span":{"begin":431,"end":624},"obj":"Sentence"},{"id":"T7","span":{"begin":625,"end":635},"obj":"Sentence"},{"id":"T8","span":{"begin":636,"end":761},"obj":"Sentence"},{"id":"T9","span":{"begin":762,"end":968},"obj":"Sentence"},{"id":"T10","span":{"begin":969,"end":1132},"obj":"Sentence"},{"id":"T11","span":{"begin":1133,"end":1141},"obj":"Sentence"},{"id":"T12","span":{"begin":1142,"end":1248},"obj":"Sentence"},{"id":"T13","span":{"begin":1249,"end":1370},"obj":"Sentence"},{"id":"T14","span":{"begin":1371,"end":1539},"obj":"Sentence"},{"id":"T15","span":{"begin":1540,"end":1648},"obj":"Sentence"},{"id":"T16","span":{"begin":1649,"end":1660},"obj":"Sentence"},{"id":"T17","span":{"begin":1661,"end":1823},"obj":"Sentence"},{"id":"T18","span":{"begin":1824,"end":2076},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":128},"obj":"Sentence"},{"id":"T2","span":{"begin":129,"end":139},"obj":"Sentence"},{"id":"T3","span":{"begin":140,"end":296},"obj":"Sentence"},{"id":"T4","span":{"begin":297,"end":321},"obj":"Sentence"},{"id":"T5","span":{"begin":322,"end":430},"obj":"Sentence"},{"id":"T6","span":{"begin":431,"end":624},"obj":"Sentence"},{"id":"T7","span":{"begin":625,"end":635},"obj":"Sentence"},{"id":"T8","span":{"begin":636,"end":761},"obj":"Sentence"},{"id":"T9","span":{"begin":762,"end":968},"obj":"Sentence"},{"id":"T10","span":{"begin":969,"end":1132},"obj":"Sentence"},{"id":"T11","span":{"begin":1133,"end":1141},"obj":"Sentence"},{"id":"T12","span":{"begin":1142,"end":1248},"obj":"Sentence"},{"id":"T13","span":{"begin":1249,"end":1370},"obj":"Sentence"},{"id":"T14","span":{"begin":1371,"end":1539},"obj":"Sentence"},{"id":"T15","span":{"begin":1540,"end":1648},"obj":"Sentence"},{"id":"T16","span":{"begin":1649,"end":1660},"obj":"Sentence"},{"id":"T17","span":{"begin":1661,"end":1823},"obj":"Sentence"},{"id":"T18","span":{"begin":1824,"end":2076},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T16","pred":"source","obj":"Inflammaging"},{"subj":"T17","pred":"source","obj":"Inflammaging"},{"subj":"T18","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T16","pred":"source","obj":"Inflammaging"},{"subj":"T17","pred":"source","obj":"Inflammaging"},{"subj":"T18","pred":"source","obj":"Inflammaging"}]},{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":38,"end":47},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":423,"end":429},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":493,"end":502},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":614,"end":623},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":683,"end":700},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1354,"end":1363},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1430,"end":1439},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1638,"end":1647},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":2042,"end":2051},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005550"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0021178"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0005550"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0005550"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0007576"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005550"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0005550"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0005550"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0005550"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T6","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T7","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T8","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T9","pred":"source","obj":"PMID_GLOBAL"}]},{"project":"Wangshuguang","denotations":[{"id":"T1","span":{"begin":246,"end":257},"obj":"B-Variation"},{"id":"T2","span":{"begin":411,"end":419},"obj":"B-Variation"},{"id":"T3","span":{"begin":541,"end":547},"obj":"B-Negative_Function"},{"id":"T4","span":{"begin":1571,"end":1583},"obj":"B-Variation"},{"id":"T5","span":{"begin":1603,"end":1607},"obj":"B-Molecular_Activity"},{"id":"T6","span":{"begin":1608,"end":1612},"obj":"I-Molecular_Activity"},{"id":"T7","span":{"begin":1613,"end":1618},"obj":"I-Molecular_Activity"},{"id":"T8","span":{"begin":1786,"end":1788},"obj":"B-Negtive_Regulation"},{"id":"T9","span":{"begin":1955,"end":1963},"obj":"B-Variation"},{"id":"T10","span":{"begin":2032,"end":2036},"obj":"B-Negative_Function"},{"id":"T11","span":{"begin":2037,"end":2041},"obj":"I-Negative_Function"},{"id":"T12","span":{"begin":2042,"end":2051},"obj":"I-Negative_Function"}],"attributes":[{"subj":"T1","pred":"source","obj":"Wangshuguang"},{"subj":"T2","pred":"source","obj":"Wangshuguang"},{"subj":"T3","pred":"source","obj":"Wangshuguang"},{"subj":"T4","pred":"source","obj":"Wangshuguang"},{"subj":"T5","pred":"source","obj":"Wangshuguang"},{"subj":"T6","pred":"source","obj":"Wangshuguang"},{"subj":"T7","pred":"source","obj":"Wangshuguang"},{"subj":"T8","pred":"source","obj":"Wangshuguang"},{"subj":"T9","pred":"source","obj":"Wangshuguang"},{"subj":"T10","pred":"source","obj":"Wangshuguang"},{"subj":"T11","pred":"source","obj":"Wangshuguang"},{"subj":"T12","pred":"source","obj":"Wangshuguang"}]},{"project":"123123123","denotations":[{"id":"T1","span":{"begin":246,"end":257},"obj":"B-Variation"},{"id":"T2","span":{"begin":411,"end":419},"obj":"B-Variation"},{"id":"T3","span":{"begin":541,"end":547},"obj":"B-Negative_Function"},{"id":"T4","span":{"begin":1571,"end":1583},"obj":"B-Variation"},{"id":"T5","span":{"begin":1603,"end":1607},"obj":"B-Molecular_Activity"},{"id":"T6","span":{"begin":1608,"end":1612},"obj":"I-Molecular_Activity"},{"id":"T7","span":{"begin":1613,"end":1618},"obj":"I-Molecular_Activity"},{"id":"T8","span":{"begin":1786,"end":1788},"obj":"B-Negtive_Regulation"},{"id":"T9","span":{"begin":1955,"end":1963},"obj":"B-Variation"},{"id":"T10","span":{"begin":2032,"end":2036},"obj":"B-Negative_Function"},{"id":"T11","span":{"begin":2037,"end":2041},"obj":"I-Negative_Function"},{"id":"T12","span":{"begin":2042,"end":2051},"obj":"I-Negative_Function"}],"attributes":[{"subj":"T1","pred":"source","obj":"123123123"},{"subj":"T2","pred":"source","obj":"123123123"},{"subj":"T3","pred":"source","obj":"123123123"},{"subj":"T4","pred":"source","obj":"123123123"},{"subj":"T5","pred":"source","obj":"123123123"},{"subj":"T6","pred":"source","obj":"123123123"},{"subj":"T7","pred":"source","obj":"123123123"},{"subj":"T8","pred":"source","obj":"123123123"},{"subj":"T9","pred":"source","obj":"123123123"},{"subj":"T10","pred":"source","obj":"123123123"},{"subj":"T11","pred":"source","obj":"123123123"},{"subj":"T12","pred":"source","obj":"123123123"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Inflammaging","color":"#ec93bb","default":true},{"id":"PMID_GLOBAL","color":"#93d5ec"},{"id":"Wangshuguang","color":"#ece993"},{"id":"123123123","color":"#cf93ec"}]}]}}