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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-65 Sentence denotes Oral budesonide in the treatment of chronic refractory pouchitis.
T2 66-77 Sentence denotes BACKGROUND:
T3 78-181 Sentence denotes Pouchitis is the major long-term complication after ileal-pouch nal anastomosis for ulcerative colitis.
T4 182-286 Sentence denotes Ten to 15% of patients develop a chronic pouchitis, either treatment responsive or treatment refractory.
T5 287-291 Sentence denotes AIM:
T6 292-434 Sentence denotes To evaluate the efficacy of oral budesonide in inducing remission and improving quality of life in patients with chronic refractory pouchitis.
T7 435-443 Sentence denotes METHODS:
T8 444-623 Sentence denotes Twenty consecutive patients with active pouchitis, not responding after 1 month of antibiotic treatment were treated with budesonide controlled ileal release 9 mg/day for 8 weeks.
T9 624-766 Sentence denotes Symptomatic, endoscopic and histological evaluations were undertaken before and after treatment according to Pouchitis Disease Activity Index.
T10 767-960 Sentence denotes Remission was defined as a combination of Pouchitis Disease Activity Index clinical score of < or = 2, endoscopic score of < or = 1 and total Pouchitis Disease Activity Index score of < or = 4.
T11 961-1044 Sentence denotes The quality of life was assessed with the Inflammatory Bowel Disease Questionnaire.
T12 1045-1053 Sentence denotes RESULTS:
T13 1054-1102 Sentence denotes Fifteen of 20 patients (75%) achieved remission.
T14 1103-1252 Sentence denotes The median total Pouchitis Disease Activity Index scores before and after therapy were, respectively, 14 (range 9-16) and 3 (range 2-10) (P < 0.001).
T15 1253-1397 Sentence denotes The median Inflammatory Bowel Disease Questionnaire score also significantly improved from 105 (range 77-175) to 180 (range 85-220) (P < 0.001).
T16 1398-1409 Sentence denotes CONCLUSION:
T17 1410-1586 Sentence denotes Eight-week treatment with oral budesonide appears effective in inducing remission in patients with active pouchitis refractory to antibiotic treatment in this open-label study.
T1 0-65 Sentence denotes Oral budesonide in the treatment of chronic refractory pouchitis.
T2 66-77 Sentence denotes BACKGROUND:
T3 78-181 Sentence denotes Pouchitis is the major long-term complication after ileal-pouch nal anastomosis for ulcerative colitis.
T4 182-286 Sentence denotes Ten to 15% of patients develop a chronic pouchitis, either treatment responsive or treatment refractory.
T5 287-291 Sentence denotes AIM:
T6 292-434 Sentence denotes To evaluate the efficacy of oral budesonide in inducing remission and improving quality of life in patients with chronic refractory pouchitis.
T7 435-443 Sentence denotes METHODS:
T8 444-623 Sentence denotes Twenty consecutive patients with active pouchitis, not responding after 1 month of antibiotic treatment were treated with budesonide controlled ileal release 9 mg/day for 8 weeks.
T9 624-766 Sentence denotes Symptomatic, endoscopic and histological evaluations were undertaken before and after treatment according to Pouchitis Disease Activity Index.
T10 767-960 Sentence denotes Remission was defined as a combination of Pouchitis Disease Activity Index clinical score of < or = 2, endoscopic score of < or = 1 and total Pouchitis Disease Activity Index score of < or = 4.
T11 961-1044 Sentence denotes The quality of life was assessed with the Inflammatory Bowel Disease Questionnaire.
T12 1045-1053 Sentence denotes RESULTS:
T13 1054-1102 Sentence denotes Fifteen of 20 patients (75%) achieved remission.
T14 1103-1252 Sentence denotes The median total Pouchitis Disease Activity Index scores before and after therapy were, respectively, 14 (range 9-16) and 3 (range 2-10) (P < 0.001).
T15 1253-1397 Sentence denotes The median Inflammatory Bowel Disease Questionnaire score also significantly improved from 105 (range 77-175) to 180 (range 85-220) (P < 0.001).
T16 1398-1409 Sentence denotes CONCLUSION:
T17 1410-1586 Sentence denotes Eight-week treatment with oral budesonide appears effective in inducing remission in patients with active pouchitis refractory to antibiotic treatment in this open-label study.