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PubMed:17451546 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes The effect of age on prostaglandin-synthesizing enzymes in the development of gingivitis.
T2 90-115 Sentence denotes BACKGROUND AND OBJECTIVE:
T3 116-298 Sentence denotes The aim of this study was to identify the expression of cyclooxygenase-1, cyclooxygenase-2, cyclooxygenase-3, and microsomal prostaglandin E synthase-1 in young and elderly subjects.
T4 299-320 Sentence denotes MATERIAL AND METHODS:
T5 321-430 Sentence denotes Periodontally healthy subjects were divided into young (18-30 years, n = 7) and elderly (46-77 years, n = 7).
T6 431-471 Sentence denotes A gingival biopsy was taken at baseline.
T7 472-567 Sentence denotes After experimental gingivitis, clinical examination was repeated and a second biopsy was taken.
T8 568-728 Sentence denotes The expression of cyclooxygenase-1, cyclooxygenase-2, cyclooxygenase-3, and microsomal prostaglandin E synthase-1 was analyzed by means of immunohistochemistry.
T9 729-737 Sentence denotes RESULTS:
T10 738-923 Sentence denotes In both healthy age groups, cyclooxygenase-1 and microsomal prostaglandin E synthase-1 were expressed in epithelial cells, endothelial cells and fibroblast-like connective tissue cells.
T11 924-990 Sentence denotes Cyclooxygenase-1 was found in Langerhans' cells of the epithelium.
T12 991-1217 Sentence denotes Cyclooxygenase-2 expression was observed in cells exhibiting the morphology of epithelial mitosis cells, and the expression of cyclooxygenase-2 in periodontally healthy elderly subjects was significantly lower (p < or = 0.05).
T13 1218-1338 Sentence denotes Following experimental gingivitis, cyclooxygenase-1 and microsomal prostaglandin E synthase-1 expression did not change.
T14 1339-1446 Sentence denotes However, the expression of cyclooxygenase-2 was significantly increased in both age groups (p < or = 0.05).
T15 1447-1507 Sentence denotes Cyclooxygenase-3 was not detected in any group investigated.
T16 1508-1519 Sentence denotes CONCLUSION:
T17 1520-1689 Sentence denotes Cyclooxygenase-1 and microsomal prostaglandin E synthase-1 were expressed constitutively in gingival tissue, and expression was unaffected by age or inflammation states.
T18 1690-1769 Sentence denotes In contrast, the expression of cyclooxygenase-2 was weaker in elderly subjects.
T19 1770-1860 Sentence denotes In the course of experimental gingivitis, cyclooxygenase-2 was induced in both age groups.
T1 0-89 Sentence denotes The effect of age on prostaglandin-synthesizing enzymes in the development of gingivitis.
T2 90-115 Sentence denotes BACKGROUND AND OBJECTIVE:
T3 116-298 Sentence denotes The aim of this study was to identify the expression of cyclooxygenase-1, cyclooxygenase-2, cyclooxygenase-3, and microsomal prostaglandin E synthase-1 in young and elderly subjects.
T4 299-320 Sentence denotes MATERIAL AND METHODS:
T5 321-430 Sentence denotes Periodontally healthy subjects were divided into young (18-30 years, n = 7) and elderly (46-77 years, n = 7).
T6 431-471 Sentence denotes A gingival biopsy was taken at baseline.
T7 472-567 Sentence denotes After experimental gingivitis, clinical examination was repeated and a second biopsy was taken.
T8 568-728 Sentence denotes The expression of cyclooxygenase-1, cyclooxygenase-2, cyclooxygenase-3, and microsomal prostaglandin E synthase-1 was analyzed by means of immunohistochemistry.
T9 729-737 Sentence denotes RESULTS:
T10 738-923 Sentence denotes In both healthy age groups, cyclooxygenase-1 and microsomal prostaglandin E synthase-1 were expressed in epithelial cells, endothelial cells and fibroblast-like connective tissue cells.
T11 924-990 Sentence denotes Cyclooxygenase-1 was found in Langerhans' cells of the epithelium.
T12 991-1217 Sentence denotes Cyclooxygenase-2 expression was observed in cells exhibiting the morphology of epithelial mitosis cells, and the expression of cyclooxygenase-2 in periodontally healthy elderly subjects was significantly lower (p < or = 0.05).
T13 1218-1338 Sentence denotes Following experimental gingivitis, cyclooxygenase-1 and microsomal prostaglandin E synthase-1 expression did not change.
T14 1339-1446 Sentence denotes However, the expression of cyclooxygenase-2 was significantly increased in both age groups (p < or = 0.05).
T15 1447-1507 Sentence denotes Cyclooxygenase-3 was not detected in any group investigated.
T16 1508-1519 Sentence denotes CONCLUSION:
T17 1520-1689 Sentence denotes Cyclooxygenase-1 and microsomal prostaglandin E synthase-1 were expressed constitutively in gingival tissue, and expression was unaffected by age or inflammation states.
T18 1690-1769 Sentence denotes In contrast, the expression of cyclooxygenase-2 was weaker in elderly subjects.
T19 1770-1860 Sentence denotes In the course of experimental gingivitis, cyclooxygenase-2 was induced in both age groups.