Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-89 |
Sentence |
denotes |
The effect of age on prostaglandin-synthesizing enzymes in the development of gingivitis. |
T2 |
90-115 |
Sentence |
denotes |
BACKGROUND AND OBJECTIVE: |
T3 |
116-298 |
Sentence |
denotes |
The aim of this study was to identify the expression of cyclooxygenase-1, cyclooxygenase-2, cyclooxygenase-3, and microsomal prostaglandin E synthase-1 in young and elderly subjects. |
T4 |
299-320 |
Sentence |
denotes |
MATERIAL AND METHODS: |
T5 |
321-430 |
Sentence |
denotes |
Periodontally healthy subjects were divided into young (18-30 years, n = 7) and elderly (46-77 years, n = 7). |
T6 |
431-471 |
Sentence |
denotes |
A gingival biopsy was taken at baseline. |
T7 |
472-567 |
Sentence |
denotes |
After experimental gingivitis, clinical examination was repeated and a second biopsy was taken. |
T8 |
568-728 |
Sentence |
denotes |
The expression of cyclooxygenase-1, cyclooxygenase-2, cyclooxygenase-3, and microsomal prostaglandin E synthase-1 was analyzed by means of immunohistochemistry. |
T9 |
729-737 |
Sentence |
denotes |
RESULTS: |
T10 |
738-923 |
Sentence |
denotes |
In both healthy age groups, cyclooxygenase-1 and microsomal prostaglandin E synthase-1 were expressed in epithelial cells, endothelial cells and fibroblast-like connective tissue cells. |
T11 |
924-990 |
Sentence |
denotes |
Cyclooxygenase-1 was found in Langerhans' cells of the epithelium. |
T12 |
991-1217 |
Sentence |
denotes |
Cyclooxygenase-2 expression was observed in cells exhibiting the morphology of epithelial mitosis cells, and the expression of cyclooxygenase-2 in periodontally healthy elderly subjects was significantly lower (p < or = 0.05). |
T13 |
1218-1338 |
Sentence |
denotes |
Following experimental gingivitis, cyclooxygenase-1 and microsomal prostaglandin E synthase-1 expression did not change. |
T14 |
1339-1446 |
Sentence |
denotes |
However, the expression of cyclooxygenase-2 was significantly increased in both age groups (p < or = 0.05). |
T15 |
1447-1507 |
Sentence |
denotes |
Cyclooxygenase-3 was not detected in any group investigated. |
T16 |
1508-1519 |
Sentence |
denotes |
CONCLUSION: |
T17 |
1520-1689 |
Sentence |
denotes |
Cyclooxygenase-1 and microsomal prostaglandin E synthase-1 were expressed constitutively in gingival tissue, and expression was unaffected by age or inflammation states. |
T18 |
1690-1769 |
Sentence |
denotes |
In contrast, the expression of cyclooxygenase-2 was weaker in elderly subjects. |
T19 |
1770-1860 |
Sentence |
denotes |
In the course of experimental gingivitis, cyclooxygenase-2 was induced in both age groups. |
T1 |
0-89 |
Sentence |
denotes |
The effect of age on prostaglandin-synthesizing enzymes in the development of gingivitis. |
T2 |
90-115 |
Sentence |
denotes |
BACKGROUND AND OBJECTIVE: |
T3 |
116-298 |
Sentence |
denotes |
The aim of this study was to identify the expression of cyclooxygenase-1, cyclooxygenase-2, cyclooxygenase-3, and microsomal prostaglandin E synthase-1 in young and elderly subjects. |
T4 |
299-320 |
Sentence |
denotes |
MATERIAL AND METHODS: |
T5 |
321-430 |
Sentence |
denotes |
Periodontally healthy subjects were divided into young (18-30 years, n = 7) and elderly (46-77 years, n = 7). |
T6 |
431-471 |
Sentence |
denotes |
A gingival biopsy was taken at baseline. |
T7 |
472-567 |
Sentence |
denotes |
After experimental gingivitis, clinical examination was repeated and a second biopsy was taken. |
T8 |
568-728 |
Sentence |
denotes |
The expression of cyclooxygenase-1, cyclooxygenase-2, cyclooxygenase-3, and microsomal prostaglandin E synthase-1 was analyzed by means of immunohistochemistry. |
T9 |
729-737 |
Sentence |
denotes |
RESULTS: |
T10 |
738-923 |
Sentence |
denotes |
In both healthy age groups, cyclooxygenase-1 and microsomal prostaglandin E synthase-1 were expressed in epithelial cells, endothelial cells and fibroblast-like connective tissue cells. |
T11 |
924-990 |
Sentence |
denotes |
Cyclooxygenase-1 was found in Langerhans' cells of the epithelium. |
T12 |
991-1217 |
Sentence |
denotes |
Cyclooxygenase-2 expression was observed in cells exhibiting the morphology of epithelial mitosis cells, and the expression of cyclooxygenase-2 in periodontally healthy elderly subjects was significantly lower (p < or = 0.05). |
T13 |
1218-1338 |
Sentence |
denotes |
Following experimental gingivitis, cyclooxygenase-1 and microsomal prostaglandin E synthase-1 expression did not change. |
T14 |
1339-1446 |
Sentence |
denotes |
However, the expression of cyclooxygenase-2 was significantly increased in both age groups (p < or = 0.05). |
T15 |
1447-1507 |
Sentence |
denotes |
Cyclooxygenase-3 was not detected in any group investigated. |
T16 |
1508-1519 |
Sentence |
denotes |
CONCLUSION: |
T17 |
1520-1689 |
Sentence |
denotes |
Cyclooxygenase-1 and microsomal prostaglandin E synthase-1 were expressed constitutively in gingival tissue, and expression was unaffected by age or inflammation states. |
T18 |
1690-1769 |
Sentence |
denotes |
In contrast, the expression of cyclooxygenase-2 was weaker in elderly subjects. |
T19 |
1770-1860 |
Sentence |
denotes |
In the course of experimental gingivitis, cyclooxygenase-2 was induced in both age groups. |