PubMed:17451077 JSONTXT

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{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/17451077","sourcedb":"PubMed","sourceid":"17451077","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/17451077","text":"Inflammatory and growth mediators in growing preterm infants.\nLittle is understood about the optimal balance between IGF-I and antagonistic inflammatory mediators, such as IL-6, in growing preterm infants. Using a prospective cohort study, we investigated the relationship between postnatal growth of preterm infants and key growth and inflammatory mediators. We studied 51 stable, growing preterm infants (mean gestational age: 27.8 +/- 0.4 weeks, mean birth weight: 1,032.8 +/- 50.6 g). IL-6 and IL-1ra (reflecting stress/ inflammation) and IGF-I and GHBP (reflecting anabolic activity and GH sensitivity) were measured at enrollment and discharge using ELISA. During the observation period (mean 6.1 +/- 0.34 weeks) there was a significant increase in weight (1,396 +/- 81 g, p \u003c 0.0001). IGF-I increased from 46.6 +/- 4.1 to 88.7 +/- 5.2 ng/ml (p \u003c 0.001). In contrast, IL-6 decreased from 9.5 +/- 1.0 to 2.3 +/- 0.34 pg/ml (p \u003c0.001) and IL-1ra from 6,042 +/- 362 to 4,851 +/- 365 ng/ml (p = 0.007). GHBP increased from 65.8 +/- 6.7 to 82.5 +/- 7.9 ng/ml (p = 0.003). IL-6 was inversely correlated with IGF-I (p \u003c 0.001). In addition, a multiple regression model showed IGF-I levels correlated positively and IL-6 levels inversely with various parameters of growth. Growth in preterm infants is characterized by increases in IGF-I and GHBP with simultaneous decreases in IL-6 and IL-1ra. Efforts to optimally balance inflammatory and growth mediators may benefit somatic growth in infants very early in life.","tracks":[{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":61},"obj":"Sentence"},{"id":"T2","span":{"begin":62,"end":205},"obj":"Sentence"},{"id":"T3","span":{"begin":206,"end":359},"obj":"Sentence"},{"id":"T4","span":{"begin":360,"end":428},"obj":"Sentence"},{"id":"T5","span":{"begin":429,"end":467},"obj":"Sentence"},{"id":"T6","span":{"begin":468,"end":488},"obj":"Sentence"},{"id":"T7","span":{"begin":489,"end":662},"obj":"Sentence"},{"id":"T8","span":{"begin":663,"end":791},"obj":"Sentence"},{"id":"T9","span":{"begin":792,"end":860},"obj":"Sentence"},{"id":"T10","span":{"begin":861,"end":1004},"obj":"Sentence"},{"id":"T11","span":{"begin":1005,"end":1072},"obj":"Sentence"},{"id":"T12","span":{"begin":1073,"end":1126},"obj":"Sentence"},{"id":"T13","span":{"begin":1127,"end":1270},"obj":"Sentence"},{"id":"T14","span":{"begin":1271,"end":1392},"obj":"Sentence"},{"id":"T15","span":{"begin":1393,"end":1513},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":61},"obj":"Sentence"},{"id":"T2","span":{"begin":62,"end":205},"obj":"Sentence"},{"id":"T3","span":{"begin":206,"end":359},"obj":"Sentence"},{"id":"T4","span":{"begin":360,"end":428},"obj":"Sentence"},{"id":"T5","span":{"begin":429,"end":467},"obj":"Sentence"},{"id":"T6","span":{"begin":468,"end":488},"obj":"Sentence"},{"id":"T7","span":{"begin":489,"end":662},"obj":"Sentence"},{"id":"T8","span":{"begin":663,"end":791},"obj":"Sentence"},{"id":"T9","span":{"begin":792,"end":860},"obj":"Sentence"},{"id":"T10","span":{"begin":861,"end":1004},"obj":"Sentence"},{"id":"T11","span":{"begin":1005,"end":1072},"obj":"Sentence"},{"id":"T12","span":{"begin":1073,"end":1126},"obj":"Sentence"},{"id":"T13","span":{"begin":1127,"end":1270},"obj":"Sentence"},{"id":"T14","span":{"begin":1271,"end":1392},"obj":"Sentence"},{"id":"T15","span":{"begin":1393,"end":1513},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Inflammaging","color":"#ec93c1","default":true}]}]}}