Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-61 |
Sentence |
denotes |
Inflammatory and growth mediators in growing preterm infants. |
T2 |
62-205 |
Sentence |
denotes |
Little is understood about the optimal balance between IGF-I and antagonistic inflammatory mediators, such as IL-6, in growing preterm infants. |
T3 |
206-359 |
Sentence |
denotes |
Using a prospective cohort study, we investigated the relationship between postnatal growth of preterm infants and key growth and inflammatory mediators. |
T4 |
360-428 |
Sentence |
denotes |
We studied 51 stable, growing preterm infants (mean gestational age: |
T5 |
429-467 |
Sentence |
denotes |
27.8 +/- 0.4 weeks, mean birth weight: |
T6 |
468-488 |
Sentence |
denotes |
1,032.8 +/- 50.6 g). |
T7 |
489-662 |
Sentence |
denotes |
IL-6 and IL-1ra (reflecting stress/ inflammation) and IGF-I and GHBP (reflecting anabolic activity and GH sensitivity) were measured at enrollment and discharge using ELISA. |
T8 |
663-791 |
Sentence |
denotes |
During the observation period (mean 6.1 +/- 0.34 weeks) there was a significant increase in weight (1,396 +/- 81 g, p < 0.0001). |
T9 |
792-860 |
Sentence |
denotes |
IGF-I increased from 46.6 +/- 4.1 to 88.7 +/- 5.2 ng/ml (p < 0.001). |
T10 |
861-1004 |
Sentence |
denotes |
In contrast, IL-6 decreased from 9.5 +/- 1.0 to 2.3 +/- 0.34 pg/ml (p <0.001) and IL-1ra from 6,042 +/- 362 to 4,851 +/- 365 ng/ml (p = 0.007). |
T11 |
1005-1072 |
Sentence |
denotes |
GHBP increased from 65.8 +/- 6.7 to 82.5 +/- 7.9 ng/ml (p = 0.003). |
T12 |
1073-1126 |
Sentence |
denotes |
IL-6 was inversely correlated with IGF-I (p < 0.001). |
T13 |
1127-1270 |
Sentence |
denotes |
In addition, a multiple regression model showed IGF-I levels correlated positively and IL-6 levels inversely with various parameters of growth. |
T14 |
1271-1392 |
Sentence |
denotes |
Growth in preterm infants is characterized by increases in IGF-I and GHBP with simultaneous decreases in IL-6 and IL-1ra. |
T15 |
1393-1513 |
Sentence |
denotes |
Efforts to optimally balance inflammatory and growth mediators may benefit somatic growth in infants very early in life. |
T1 |
0-61 |
Sentence |
denotes |
Inflammatory and growth mediators in growing preterm infants. |
T2 |
62-205 |
Sentence |
denotes |
Little is understood about the optimal balance between IGF-I and antagonistic inflammatory mediators, such as IL-6, in growing preterm infants. |
T3 |
206-359 |
Sentence |
denotes |
Using a prospective cohort study, we investigated the relationship between postnatal growth of preterm infants and key growth and inflammatory mediators. |
T4 |
360-428 |
Sentence |
denotes |
We studied 51 stable, growing preterm infants (mean gestational age: |
T5 |
429-467 |
Sentence |
denotes |
27.8 +/- 0.4 weeks, mean birth weight: |
T6 |
468-488 |
Sentence |
denotes |
1,032.8 +/- 50.6 g). |
T7 |
489-662 |
Sentence |
denotes |
IL-6 and IL-1ra (reflecting stress/ inflammation) and IGF-I and GHBP (reflecting anabolic activity and GH sensitivity) were measured at enrollment and discharge using ELISA. |
T8 |
663-791 |
Sentence |
denotes |
During the observation period (mean 6.1 +/- 0.34 weeks) there was a significant increase in weight (1,396 +/- 81 g, p < 0.0001). |
T9 |
792-860 |
Sentence |
denotes |
IGF-I increased from 46.6 +/- 4.1 to 88.7 +/- 5.2 ng/ml (p < 0.001). |
T10 |
861-1004 |
Sentence |
denotes |
In contrast, IL-6 decreased from 9.5 +/- 1.0 to 2.3 +/- 0.34 pg/ml (p <0.001) and IL-1ra from 6,042 +/- 362 to 4,851 +/- 365 ng/ml (p = 0.007). |
T11 |
1005-1072 |
Sentence |
denotes |
GHBP increased from 65.8 +/- 6.7 to 82.5 +/- 7.9 ng/ml (p = 0.003). |
T12 |
1073-1126 |
Sentence |
denotes |
IL-6 was inversely correlated with IGF-I (p < 0.001). |
T13 |
1127-1270 |
Sentence |
denotes |
In addition, a multiple regression model showed IGF-I levels correlated positively and IL-6 levels inversely with various parameters of growth. |
T14 |
1271-1392 |
Sentence |
denotes |
Growth in preterm infants is characterized by increases in IGF-I and GHBP with simultaneous decreases in IL-6 and IL-1ra. |
T15 |
1393-1513 |
Sentence |
denotes |
Efforts to optimally balance inflammatory and growth mediators may benefit somatic growth in infants very early in life. |