PubMed:16132956 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":216,"end":234},"obj":"HP_0000855"}],"text":"Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.\nAIMS/HYPOTHESIS: The proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding TNF-alpha (TNF) has shown inconsistent associations with susceptibility to both conditions. Additionally, the coding non-synonymous variant T60N in the neighbouring LTA gene has been reported to be associated with type 2 diabetes. The present study aimed to obtain a robust assessment of the role of variation in the tightly linked TNF/LTA region in diabetes susceptibility by genotyping TNF and LTA variants in large case-control resources.\nMATERIALS AND METHODS: The G-308A and G-238A TNF promoter variants and the LTA T60N polymorphism were genotyped in two UK case samples that were ascertained for positive family history and/or early onset of type 2 diabetes (combined n=858) and in 1,257 ethnically matched controls.\nRESULTS: There were no significant associations between the T60N, G-308A or G-238A genotype and type 2 diabetes in the combined analysis (exact Cochran-Mantel-Haenszel statistic for ordered genotypes for T60N, p=0.69; for G-308A, p=0.51; for G-238A, p=0.16).\nCONCLUSIONS/INTERPRETATION: The present study, one of the largest association analyses yet reported at this locus, provides no evidence that the specific TNF or LTA variants examined influence susceptibility to type 2 diabetes. More comprehensive studies of the TNF/LTA locus in substantially larger sample sets are required to establish whether genome sequence variation at this locus truly influences susceptibility to type 2 diabetes."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"16132956-5#51#55#geners1041981","span":{"begin":1075,"end":1079},"obj":"geners1041981"},{"id":"16132956-5#195#199#geners1041981","span":{"begin":1219,"end":1223},"obj":"geners1041981"},{"id":"16132956-5#87#102#diseaseC0011860","span":{"begin":1111,"end":1126},"obj":"diseaseC0011860"}],"relations":[{"id":"51#55#geners104198187#102#diseaseC0011860","pred":"associated_with","subj":"16132956-5#51#55#geners1041981","obj":"16132956-5#87#102#diseaseC0011860"},{"id":"195#199#geners104198187#102#diseaseC0011860","pred":"associated_with","subj":"16132956-5#195#199#geners1041981","obj":"16132956-5#87#102#diseaseC0011860"}],"text":"Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.\nAIMS/HYPOTHESIS: The proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding TNF-alpha (TNF) has shown inconsistent associations with susceptibility to both conditions. Additionally, the coding non-synonymous variant T60N in the neighbouring LTA gene has been reported to be associated with type 2 diabetes. The present study aimed to obtain a robust assessment of the role of variation in the tightly linked TNF/LTA region in diabetes susceptibility by genotyping TNF and LTA variants in large case-control resources.\nMATERIALS AND METHODS: The G-308A and G-238A TNF promoter variants and the LTA T60N polymorphism were genotyped in two UK case samples that were ascertained for positive family history and/or early onset of type 2 diabetes (combined n=858) and in 1,257 ethnically matched controls.\nRESULTS: There were no significant associations between the T60N, G-308A or G-238A genotype and type 2 diabetes in the combined analysis (exact Cochran-Mantel-Haenszel statistic for ordered genotypes for T60N, p=0.69; for G-308A, p=0.51; for G-238A, p=0.16).\nCONCLUSIONS/INTERPRETATION: The present study, one of the largest association analyses yet reported at this locus, provides no evidence that the specific TNF or LTA variants examined influence susceptibility to type 2 diabetes. More comprehensive studies of the TNF/LTA locus in substantially larger sample sets are required to establish whether genome sequence variation at this locus truly influences susceptibility to type 2 diabetes."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"16132956-2#73#76#gene4049","span":{"begin":456,"end":459},"obj":"gene4049"},{"id":"16132956-2#122#137#diseaseC0011860","span":{"begin":505,"end":520},"obj":"diseaseC0011860"},{"id":"16132956-4#22#25#gene7124","span":{"begin":778,"end":781},"obj":"gene7124"},{"id":"16132956-4#184#199#diseaseC0011860","span":{"begin":940,"end":955},"obj":"diseaseC0011860"}],"relations":[{"id":"73#76#gene4049122#137#diseaseC0011860","pred":"associated_with","subj":"16132956-2#73#76#gene4049","obj":"16132956-2#122#137#diseaseC0011860"},{"id":"22#25#gene7124184#199#diseaseC0011860","pred":"associated_with","subj":"16132956-4#22#25#gene7124","obj":"16132956-4#184#199#diseaseC0011860"}],"text":"Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.\nAIMS/HYPOTHESIS: The proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding TNF-alpha (TNF) has shown inconsistent associations with susceptibility to both conditions. Additionally, the coding non-synonymous variant T60N in the neighbouring LTA gene has been reported to be associated with type 2 diabetes. The present study aimed to obtain a robust assessment of the role of variation in the tightly linked TNF/LTA region in diabetes susceptibility by genotyping TNF and LTA variants in large case-control resources.\nMATERIALS AND METHODS: The G-308A and G-238A TNF promoter variants and the LTA T60N polymorphism were genotyped in two UK case samples that were ascertained for positive family history and/or early onset of type 2 diabetes (combined n=858) and in 1,257 ethnically matched controls.\nRESULTS: There were no significant associations between the T60N, G-308A or G-238A genotype and type 2 diabetes in the combined analysis (exact Cochran-Mantel-Haenszel statistic for ordered genotypes for T60N, p=0.69; for G-308A, p=0.51; for G-238A, p=0.16).\nCONCLUSIONS/INTERPRETATION: The present study, one of the largest association analyses yet reported at this locus, provides no evidence that the specific TNF or LTA variants examined influence susceptibility to type 2 diabetes. More comprehensive studies of the TNF/LTA locus in substantially larger sample sets are required to establish whether genome sequence variation at this locus truly influences susceptibility to type 2 diabetes."}

{"project":"Wangshuguang","denotations":[{"id":"T1","span":{"begin":200,"end":212},"obj":"B-Variation"},{"id":"T2","span":{"begin":1225,"end":1231},"obj":"B-Variation"},{"id":"T3","span":{"begin":1245,"end":1251},"obj":"B-Variation"},{"id":"T4","span":{"begin":1265,"end":1271},"obj":"B-Variation"},{"id":"T5","span":{"begin":1389,"end":1397},"obj":"B-Regulation"},{"id":"T6","span":{"begin":1398,"end":1400},"obj":"I-Regulation"},{"id":"T7","span":{"begin":1401,"end":1409},"obj":"I-Regulation"}],"text":"Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.\nAIMS/HYPOTHESIS: The proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding TNF-alpha (TNF) has shown inconsistent associations with susceptibility to both conditions. Additionally, the coding non-synonymous variant T60N in the neighbouring LTA gene has been reported to be associated with type 2 diabetes. The present study aimed to obtain a robust assessment of the role of variation in the tightly linked TNF/LTA region in diabetes susceptibility by genotyping TNF and LTA variants in large case-control resources.\nMATERIALS AND METHODS: The G-308A and G-238A TNF promoter variants and the LTA T60N polymorphism were genotyped in two UK case samples that were ascertained for positive family history and/or early onset of type 2 diabetes (combined n=858) and in 1,257 ethnically matched controls.\nRESULTS: There were no significant associations between the T60N, G-308A or G-238A genotype and type 2 diabetes in the combined analysis (exact Cochran-Mantel-Haenszel statistic for ordered genotypes for T60N, p=0.69; for G-308A, p=0.51; for G-238A, p=0.16).\nCONCLUSIONS/INTERPRETATION: The present study, one of the largest association analyses yet reported at this locus, provides no evidence that the specific TNF or LTA variants examined influence susceptibility to type 2 diabetes. More comprehensive studies of the TNF/LTA locus in substantially larger sample sets are required to establish whether genome sequence variation at this locus truly influences susceptibility to type 2 diabetes."}

{"project":"123123123","denotations":[{"id":"T1","span":{"begin":200,"end":212},"obj":"B-Variation"},{"id":"T2","span":{"begin":1225,"end":1231},"obj":"B-Variation"},{"id":"T3","span":{"begin":1245,"end":1251},"obj":"B-Variation"},{"id":"T4","span":{"begin":1265,"end":1271},"obj":"B-Variation"},{"id":"T5","span":{"begin":1389,"end":1397},"obj":"B-Regulation"},{"id":"T6","span":{"begin":1398,"end":1400},"obj":"I-Regulation"},{"id":"T7","span":{"begin":1401,"end":1409},"obj":"I-Regulation"}],"text":"Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.\nAIMS/HYPOTHESIS: The proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding TNF-alpha (TNF) has shown inconsistent associations with susceptibility to both conditions. Additionally, the coding non-synonymous variant T60N in the neighbouring LTA gene has been reported to be associated with type 2 diabetes. The present study aimed to obtain a robust assessment of the role of variation in the tightly linked TNF/LTA region in diabetes susceptibility by genotyping TNF and LTA variants in large case-control resources.\nMATERIALS AND METHODS: The G-308A and G-238A TNF promoter variants and the LTA T60N polymorphism were genotyped in two UK case samples that were ascertained for positive family history and/or early onset of type 2 diabetes (combined n=858) and in 1,257 ethnically matched controls.\nRESULTS: There were no significant associations between the T60N, G-308A or G-238A genotype and type 2 diabetes in the combined analysis (exact Cochran-Mantel-Haenszel statistic for ordered genotypes for T60N, p=0.69; for G-308A, p=0.51; for G-238A, p=0.16).\nCONCLUSIONS/INTERPRETATION: The present study, one of the largest association analyses yet reported at this locus, provides no evidence that the specific TNF or LTA variants examined influence susceptibility to type 2 diabetes. More comprehensive studies of the TNF/LTA locus in substantially larger sample sets are required to establish whether genome sequence variation at this locus truly influences susceptibility to type 2 diabetes."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":216,"end":223},"obj":"gene:723961"},{"id":"T1","span":{"begin":239,"end":254},"obj":"disease:C0011860"},{"id":"T2","span":{"begin":216,"end":223},"obj":"gene:3630"},{"id":"T3","span":{"begin":239,"end":254},"obj":"disease:C0011860"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.\nAIMS/HYPOTHESIS: The proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding TNF-alpha (TNF) has shown inconsistent associations with susceptibility to both conditions. Additionally, the coding non-synonymous variant T60N in the neighbouring LTA gene has been reported to be associated with type 2 diabetes. The present study aimed to obtain a robust assessment of the role of variation in the tightly linked TNF/LTA region in diabetes susceptibility by genotyping TNF and LTA variants in large case-control resources.\nMATERIALS AND METHODS: The G-308A and G-238A TNF promoter variants and the LTA T60N polymorphism were genotyped in two UK case samples that were ascertained for positive family history and/or early onset of type 2 diabetes (combined n=858) and in 1,257 ethnically matched controls.\nRESULTS: There were no significant associations between the T60N, G-308A or G-238A genotype and type 2 diabetes in the combined analysis (exact Cochran-Mantel-Haenszel statistic for ordered genotypes for T60N, p=0.69; for G-308A, p=0.51; for G-238A, p=0.16).\nCONCLUSIONS/INTERPRETATION: The present study, one of the largest association analyses yet reported at this locus, provides no evidence that the specific TNF or LTA variants examined influence susceptibility to type 2 diabetes. More comprehensive studies of the TNF/LTA locus in substantially larger sample sets are required to establish whether genome sequence variation at this locus truly influences susceptibility to type 2 diabetes."}