Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-93 |
Sentence |
denotes |
The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions. |
T2 |
94-240 |
Sentence |
denotes |
The capacity of (CTG.CAG)n and (GAA.TTC)n repeat tracts in plasmids to induce mutations in DNA flanking regions was evaluated in Escherichia coli. |
T3 |
241-369 |
Sentence |
denotes |
Long repeats of these sequences are involved in the etiology of myotonic dystrophy type 1 and Friedreich's ataxia, respectively. |
T4 |
370-487 |
Sentence |
denotes |
Long (CTG.CAG)n (where n = 98 and 175) caused the deletion of most, or all, of the repeats and the flanking GFP gene. |
T5 |
488-546 |
Sentence |
denotes |
Deletions of 0.6-1.8 kbp were found as well as inversions. |
T6 |
547-665 |
Sentence |
denotes |
Shorter repeat tracts (where n = 0 or 17) were essentially inert, as observed for the (GAA.TTC)176-containing plasmid. |
T7 |
666-862 |
Sentence |
denotes |
The orientation of the triplet repeat sequence (TRS) relative to the unidirectional origin of replication had a pronounced effect, signaling the participation of replication and/or repair systems. |
T8 |
863-943 |
Sentence |
denotes |
Also, when the TRS was transcribed, the level of deletions was greatly elevated. |
T9 |
944-1019 |
Sentence |
denotes |
Under certain conditions, 30-50% of the products contained gross deletions. |
T10 |
1020-1161 |
Sentence |
denotes |
DNA sequence analyses of the breakpoint junctions in 47 deletions revealed the presence of 1-8-bp direct or inverted homologies in all cases. |
T11 |
1162-1317 |
Sentence |
denotes |
Also, the presence of non-B folded conformations (i.e. slipped structures, cruciforms, or triplexes) at or near the breakpoints was predicted in all cases. |
T12 |
1318-1524 |
Sentence |
denotes |
This genetic behavior, which was previously unrecognized for a TRS, may provide the basis for a new type of instability of the myotonic dystrophy protein kinase (DMPK) gene in patients with a full mutation. |