PubMed:15483270 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/15483270","sourcedb":"PubMed","sourceid":"15483270","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/15483270","text":"Regulation of intestinal ontogeny: effect of glucocorticoids and luminal microbes on galactosyltransferase and trehalase induction in mice.\nIntestinal maturation can be influenced by intrinsic factors (glucocorticoid hormones) and by extrinsic factors (resident microflora); their relative roles in ontogeny of mouse intestinal trehalase expression, a marker of general gut development, and of beta1,4-galactosyltransferase (beta GT), a marker of glycosyltransferase development, were investigated. In conventional (CONV) mice, beta GT and trehalase gene expression rapidly increased to adult levels by the fourth postnatal week. In germ-free (GF) mice, beta GT expression remained at initial low levels and was rapidly induced on reintroduction of luminal microbes of the adult gut but not of microbes characteristic of the suckling gut. Similar developmental patterns were observed for colonic galactosyl beta1,4-linked glycoconjugates, products of beta GT activity. These results indicate an essential role for microbes in the ontogeny of beta GT. In both CONV and GF mice, cartisone acetate (CA) precociously accelerated the ontogeny of beta GT and trehalase until maturation of the gut occurred (day 22). In the mature gut of CONV mice, both beta GT and trehalase are elevated and insensitive to CA; in GF mature mice, the expression of beta GT remains low, whereas the expression of trehalase was at mature levels, regardless of CA treatment. These changes in enzyme activity were accompanied by parallel changes in mRNA, implying transcriptional regulation. Thus both microbes and cortisone regulate gut ontogeny, but only suckling gut responds to CA, an intrinsic factor, whereas adult gut beta GT expression remains sensitive to microflora, an extrinsic factor. However, induction of the adult pattern of glycosyltransferase expression in mature gut requires colonization by microflora typical of adult gut, suggesting an essential role for intestinal colonization in the ontogeny of normal intestinal mucosal cell surface glycoconjugate receptors.","tracks":[{"project":"GlyCosmos6-UBERON","denotations":[{"id":"T1","span":{"begin":370,"end":373},"obj":"Body_part"},{"id":"T4","span":{"begin":779,"end":782},"obj":"Body_part"},{"id":"T7","span":{"begin":834,"end":837},"obj":"Body_part"},{"id":"T10","span":{"begin":1187,"end":1190},"obj":"Body_part"},{"id":"T13","span":{"begin":1224,"end":1227},"obj":"Body_part"},{"id":"T16","span":{"begin":1607,"end":1610},"obj":"Body_part"},{"id":"T19","span":{"begin":1639,"end":1642},"obj":"Body_part"},{"id":"T22","span":{"begin":1694,"end":1697},"obj":"Body_part"},{"id":"T25","span":{"begin":1855,"end":1858},"obj":"Body_part"},{"id":"T28","span":{"begin":1912,"end":1915},"obj":"Body_part"},{"id":"T31","span":{"begin":2019,"end":2023},"obj":"Body_part"},{"id":"T32","span":{"begin":2024,"end":2031},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A2","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A3","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0004907"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A5","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A6","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0004907"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A8","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A9","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0004907"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A11","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A12","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0004907"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A14","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A15","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0004907"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A17","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A18","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0004907"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A20","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A21","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0004907"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A23","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A24","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0004907"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A26","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A27","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0004907"},{"id":"A28","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A29","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A30","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0004907"},{"id":"A31","pred":"uberon_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"A32","pred":"uberon_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/UBERON_0002416"},{"subj":"T1","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T4","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T7","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T10","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T13","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T16","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T19","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T22","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T25","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T28","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T31","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T32","pred":"source","obj":"GlyCosmos6-UBERON"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":14,"end":24},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T2","span":{"begin":140,"end":150},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T3","span":{"begin":317,"end":327},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T4","span":{"begin":370,"end":373},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T5","span":{"begin":779,"end":782},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T6","span":{"begin":834,"end":837},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T7","span":{"begin":888,"end":895},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T8","span":{"begin":1187,"end":1190},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T9","span":{"begin":1224,"end":1227},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T10","span":{"begin":1607,"end":1610},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T11","span":{"begin":1639,"end":1642},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T12","span":{"begin":1694,"end":1697},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T13","span":{"begin":1855,"end":1858},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T14","span":{"begin":1868,"end":1880},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T15","span":{"begin":1912,"end":1915},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T16","span":{"begin":1950,"end":1960},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T17","span":{"begin":1961,"end":1973},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T18","span":{"begin":2000,"end":2010},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T2","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T3","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T4","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T5","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T6","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T7","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T8","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T9","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T10","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T11","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T12","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T13","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T14","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T15","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T16","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T17","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T18","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":139},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":140,"end":498},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":499,"end":629},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":630,"end":838},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":839,"end":968},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":969,"end":1050},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":1051,"end":1209},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1210,"end":1448},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":1449,"end":1564},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1565,"end":1770},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1771,"end":2057},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":139},"obj":"Sentence"},{"id":"T2","span":{"begin":140,"end":498},"obj":"Sentence"},{"id":"T3","span":{"begin":499,"end":629},"obj":"Sentence"},{"id":"T4","span":{"begin":630,"end":838},"obj":"Sentence"},{"id":"T5","span":{"begin":839,"end":968},"obj":"Sentence"},{"id":"T6","span":{"begin":969,"end":1050},"obj":"Sentence"},{"id":"T7","span":{"begin":1051,"end":1209},"obj":"Sentence"},{"id":"T8","span":{"begin":1210,"end":1448},"obj":"Sentence"},{"id":"T9","span":{"begin":1449,"end":1564},"obj":"Sentence"},{"id":"T10","span":{"begin":1565,"end":1770},"obj":"Sentence"},{"id":"T11","span":{"begin":1771,"end":2057},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":139},"obj":"Sentence"},{"id":"T2","span":{"begin":140,"end":498},"obj":"Sentence"},{"id":"T3","span":{"begin":499,"end":629},"obj":"Sentence"},{"id":"T4","span":{"begin":630,"end":838},"obj":"Sentence"},{"id":"T5","span":{"begin":839,"end":968},"obj":"Sentence"},{"id":"T6","span":{"begin":969,"end":1050},"obj":"Sentence"},{"id":"T7","span":{"begin":1051,"end":1209},"obj":"Sentence"},{"id":"T8","span":{"begin":1210,"end":1448},"obj":"Sentence"},{"id":"T9","span":{"begin":1449,"end":1564},"obj":"Sentence"},{"id":"T10","span":{"begin":1565,"end":1770},"obj":"Sentence"},{"id":"T11","span":{"begin":1771,"end":2057},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"}]},{"project":"GlyCosmos6-CLO","denotations":[{"id":"T1","span":{"begin":311,"end":316},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T2","span":{"begin":959,"end":967},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T3","span":{"begin":1473,"end":1481},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T4","span":{"begin":2019,"end":2023},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T2","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T3","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T4","pred":"source","obj":"GlyCosmos6-CLO"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":134,"end":138},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":311,"end":316},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":522,"end":526},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":648,"end":652},"obj":"OrganismTaxon"},{"id":"T9","span":{"begin":1071,"end":1075},"obj":"OrganismTaxon"},{"id":"T11","span":{"begin":1236,"end":1240},"obj":"OrganismTaxon"},{"id":"T13","span":{"begin":1318,"end":1322},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:10088"},{"id":"A2","pred":"db_id","subj":"T1","obj":"NCBItxid:10095"},{"id":"A3","pred":"db_id","subj":"T3","obj":"NCBItxid:10088"},{"id":"A4","pred":"db_id","subj":"T3","obj":"NCBItxid:10090"},{"id":"A5","pred":"db_id","subj":"T5","obj":"NCBItxid:10088"},{"id":"A6","pred":"db_id","subj":"T5","obj":"NCBItxid:10095"},{"id":"A7","pred":"db_id","subj":"T7","obj":"NCBItxid:10088"},{"id":"A8","pred":"db_id","subj":"T7","obj":"NCBItxid:10095"},{"id":"A9","pred":"db_id","subj":"T9","obj":"NCBItxid:10088"},{"id":"A10","pred":"db_id","subj":"T9","obj":"NCBItxid:10095"},{"id":"A11","pred":"db_id","subj":"T11","obj":"NCBItxid:10088"},{"id":"A12","pred":"db_id","subj":"T11","obj":"NCBItxid:10095"},{"id":"A13","pred":"db_id","subj":"T13","obj":"NCBItxid:10088"},{"id":"A14","pred":"db_id","subj":"T13","obj":"NCBItxid:10095"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T3","pred":"source","obj":"NCBITAXON"},{"subj":"T5","pred":"source","obj":"NCBITAXON"},{"subj":"T7","pred":"source","obj":"NCBITAXON"},{"subj":"T9","pred":"source","obj":"NCBITAXON"},{"subj":"T11","pred":"source","obj":"NCBITAXON"},{"subj":"T13","pred":"source","obj":"NCBITAXON"}]},{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":111,"end":120},"obj":"http://www.uniprot.org/uniprot/O43280"},{"id":"T2","span":{"begin":328,"end":337},"obj":"http://www.uniprot.org/uniprot/O43280"},{"id":"T3","span":{"begin":540,"end":549},"obj":"http://www.uniprot.org/uniprot/O43280"},{"id":"T4","span":{"begin":1153,"end":1162},"obj":"http://www.uniprot.org/uniprot/O43280"},{"id":"T5","span":{"begin":1259,"end":1268},"obj":"http://www.uniprot.org/uniprot/O43280"},{"id":"T6","span":{"begin":1389,"end":1398},"obj":"http://www.uniprot.org/uniprot/O43280"},{"id":"T7","span":{"begin":183,"end":200},"obj":"http://www.uniprot.org/uniprot/P27352"},{"id":"T8","span":{"begin":1662,"end":1678},"obj":"http://www.uniprot.org/uniprot/P27352"},{"id":"T9","span":{"begin":430,"end":432},"obj":"http://www.uniprot.org/uniprot/Q9NYU2"},{"id":"T10","span":{"begin":533,"end":535},"obj":"http://www.uniprot.org/uniprot/Q9NYU2"},{"id":"T11","span":{"begin":659,"end":661},"obj":"http://www.uniprot.org/uniprot/Q9NYU2"},{"id":"T12","span":{"begin":956,"end":958},"obj":"http://www.uniprot.org/uniprot/Q9NYU2"},{"id":"T13","span":{"begin":1047,"end":1049},"obj":"http://www.uniprot.org/uniprot/Q9NYU2"},{"id":"T14","span":{"begin":1146,"end":1148},"obj":"http://www.uniprot.org/uniprot/Q9NYU2"},{"id":"T15","span":{"begin":1252,"end":1254},"obj":"http://www.uniprot.org/uniprot/Q9NYU2"},{"id":"T16","span":{"begin":1347,"end":1349},"obj":"http://www.uniprot.org/uniprot/Q9NYU2"},{"id":"T17","span":{"begin":1703,"end":1705},"obj":"http://www.uniprot.org/uniprot/Q9NYU2"},{"id":"T18","span":{"begin":430,"end":432},"obj":"http://www.uniprot.org/uniprot/P51161"},{"id":"T19","span":{"begin":533,"end":535},"obj":"http://www.uniprot.org/uniprot/P51161"},{"id":"T20","span":{"begin":659,"end":661},"obj":"http://www.uniprot.org/uniprot/P51161"},{"id":"T21","span":{"begin":956,"end":958},"obj":"http://www.uniprot.org/uniprot/P51161"},{"id":"T22","span":{"begin":1047,"end":1049},"obj":"http://www.uniprot.org/uniprot/P51161"},{"id":"T23","span":{"begin":1146,"end":1148},"obj":"http://www.uniprot.org/uniprot/P51161"},{"id":"T24","span":{"begin":1252,"end":1254},"obj":"http://www.uniprot.org/uniprot/P51161"},{"id":"T25","span":{"begin":1347,"end":1349},"obj":"http://www.uniprot.org/uniprot/P51161"},{"id":"T26","span":{"begin":1703,"end":1705},"obj":"http://www.uniprot.org/uniprot/P51161"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-human"},{"subj":"T2","pred":"source","obj":"uniprot-human"},{"subj":"T3","pred":"source","obj":"uniprot-human"},{"subj":"T4","pred":"source","obj":"uniprot-human"},{"subj":"T5","pred":"source","obj":"uniprot-human"},{"subj":"T6","pred":"source","obj":"uniprot-human"},{"subj":"T7","pred":"source","obj":"uniprot-human"},{"subj":"T8","pred":"source","obj":"uniprot-human"},{"subj":"T9","pred":"source","obj":"uniprot-human"},{"subj":"T10","pred":"source","obj":"uniprot-human"},{"subj":"T11","pred":"source","obj":"uniprot-human"},{"subj":"T12","pred":"source","obj":"uniprot-human"},{"subj":"T13","pred":"source","obj":"uniprot-human"},{"subj":"T14","pred":"source","obj":"uniprot-human"},{"subj":"T15","pred":"source","obj":"uniprot-human"},{"subj":"T16","pred":"source","obj":"uniprot-human"},{"subj":"T17","pred":"source","obj":"uniprot-human"},{"subj":"T18","pred":"source","obj":"uniprot-human"},{"subj":"T19","pred":"source","obj":"uniprot-human"},{"subj":"T20","pred":"source","obj":"uniprot-human"},{"subj":"T21","pred":"source","obj":"uniprot-human"},{"subj":"T22","pred":"source","obj":"uniprot-human"},{"subj":"T23","pred":"source","obj":"uniprot-human"},{"subj":"T24","pred":"source","obj":"uniprot-human"},{"subj":"T25","pred":"source","obj":"uniprot-human"},{"subj":"T26","pred":"source","obj":"uniprot-human"}]},{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":85,"end":106},"obj":"http://www.uniprot.org/uniprot/P23336"},{"id":"T2","span":{"begin":402,"end":423},"obj":"http://www.uniprot.org/uniprot/P23336"},{"id":"T3","span":{"begin":111,"end":120},"obj":"http://www.uniprot.org/uniprot/Q9JLT2"},{"id":"T4","span":{"begin":328,"end":337},"obj":"http://www.uniprot.org/uniprot/Q9JLT2"},{"id":"T5","span":{"begin":540,"end":549},"obj":"http://www.uniprot.org/uniprot/Q9JLT2"},{"id":"T6","span":{"begin":1153,"end":1162},"obj":"http://www.uniprot.org/uniprot/Q9JLT2"},{"id":"T7","span":{"begin":1259,"end":1268},"obj":"http://www.uniprot.org/uniprot/Q9JLT2"},{"id":"T8","span":{"begin":1389,"end":1398},"obj":"http://www.uniprot.org/uniprot/Q9JLT2"},{"id":"T9","span":{"begin":183,"end":200},"obj":"http://www.uniprot.org/uniprot/P52787"},{"id":"T10","span":{"begin":1662,"end":1678},"obj":"http://www.uniprot.org/uniprot/P52787"},{"id":"T11","span":{"begin":430,"end":432},"obj":"http://www.uniprot.org/uniprot/P51162"},{"id":"T12","span":{"begin":533,"end":535},"obj":"http://www.uniprot.org/uniprot/P51162"},{"id":"T13","span":{"begin":659,"end":661},"obj":"http://www.uniprot.org/uniprot/P51162"},{"id":"T14","span":{"begin":956,"end":958},"obj":"http://www.uniprot.org/uniprot/P51162"},{"id":"T15","span":{"begin":1047,"end":1049},"obj":"http://www.uniprot.org/uniprot/P51162"},{"id":"T16","span":{"begin":1146,"end":1148},"obj":"http://www.uniprot.org/uniprot/P51162"},{"id":"T17","span":{"begin":1252,"end":1254},"obj":"http://www.uniprot.org/uniprot/P51162"},{"id":"T18","span":{"begin":1347,"end":1349},"obj":"http://www.uniprot.org/uniprot/P51162"},{"id":"T19","span":{"begin":1703,"end":1705},"obj":"http://www.uniprot.org/uniprot/P51162"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-mouse"},{"subj":"T2","pred":"source","obj":"uniprot-mouse"},{"subj":"T3","pred":"source","obj":"uniprot-mouse"},{"subj":"T4","pred":"source","obj":"uniprot-mouse"},{"subj":"T5","pred":"source","obj":"uniprot-mouse"},{"subj":"T6","pred":"source","obj":"uniprot-mouse"},{"subj":"T7","pred":"source","obj":"uniprot-mouse"},{"subj":"T8","pred":"source","obj":"uniprot-mouse"},{"subj":"T9","pred":"source","obj":"uniprot-mouse"},{"subj":"T10","pred":"source","obj":"uniprot-mouse"},{"subj":"T11","pred":"source","obj":"uniprot-mouse"},{"subj":"T12","pred":"source","obj":"uniprot-mouse"},{"subj":"T13","pred":"source","obj":"uniprot-mouse"},{"subj":"T14","pred":"source","obj":"uniprot-mouse"},{"subj":"T15","pred":"source","obj":"uniprot-mouse"},{"subj":"T16","pred":"source","obj":"uniprot-mouse"},{"subj":"T17","pred":"source","obj":"uniprot-mouse"},{"subj":"T18","pred":"source","obj":"uniprot-mouse"},{"subj":"T19","pred":"source","obj":"uniprot-mouse"}]},{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":217,"end":225},"obj":"http://purl.bioontology.org/ontology/STY/T125"},{"id":"T2","span":{"begin":425,"end":429},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T3","span":{"begin":425,"end":429},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T4","span":{"begin":528,"end":532},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T5","span":{"begin":528,"end":532},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T6","span":{"begin":654,"end":658},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T7","span":{"begin":654,"end":658},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T8","span":{"begin":951,"end":955},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T9","span":{"begin":951,"end":955},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T10","span":{"begin":1042,"end":1046},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T11","span":{"begin":1042,"end":1046},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T12","span":{"begin":1100,"end":1112},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/311126"},{"id":"T13","span":{"begin":1141,"end":1145},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T14","span":{"begin":1141,"end":1145},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T15","span":{"begin":1201,"end":1204},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/82391"},{"id":"T16","span":{"begin":1247,"end":1251},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T17","span":{"begin":1247,"end":1251},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T18","span":{"begin":1342,"end":1346},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T19","span":{"begin":1342,"end":1346},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T20","span":{"begin":1502,"end":1510},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/871272"},{"id":"T21","span":{"begin":1698,"end":1702},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T22","span":{"begin":1698,"end":1702},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T23","span":{"begin":2047,"end":2056},"obj":"http://purl.bioontology.org/ontology/STY/T192"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T2","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T3","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T4","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T5","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T6","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T7","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T8","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T9","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T10","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T11","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T12","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T13","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T14","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T15","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T16","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T17","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T18","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T19","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T20","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T21","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T22","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T23","pred":"source","obj":"GlycoBiology-NCBITAXON"}]},{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T2","span":{"begin":1553,"end":1563},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T3","span":{"begin":1598,"end":1606},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T4","span":{"begin":370,"end":385},"obj":"http://purl.obolibrary.org/obo/GO_0048565"},{"id":"T5","span":{"begin":374,"end":385},"obj":"http://purl.obolibrary.org/obo/GO_0032502"},{"id":"T6","span":{"begin":467,"end":478},"obj":"http://purl.obolibrary.org/obo/GO_0032502"},{"id":"T7","span":{"begin":550,"end":565},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T8","span":{"begin":956,"end":967},"obj":"http://purl.obolibrary.org/obo/GO_0015020"},{"id":"T9","span":{"begin":1096,"end":1098},"obj":"http://purl.obolibrary.org/obo/GO_0033968"},{"id":"T10","span":{"begin":1301,"end":1303},"obj":"http://purl.obolibrary.org/obo/GO_0033968"},{"id":"T11","span":{"begin":1435,"end":1437},"obj":"http://purl.obolibrary.org/obo/GO_0033968"},{"id":"T12","span":{"begin":1655,"end":1657},"obj":"http://purl.obolibrary.org/obo/GO_0033968"},{"id":"T13","span":{"begin":1466,"end":1481},"obj":"http://purl.obolibrary.org/obo/GO_0003824"},{"id":"T14","span":{"begin":1537,"end":1552},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T15","span":{"begin":1725,"end":1734},"obj":"http://purl.obolibrary.org/obo/GO_0046960"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-BP"},{"subj":"T2","pred":"source","obj":"GO-BP"},{"subj":"T3","pred":"source","obj":"GO-BP"},{"subj":"T4","pred":"source","obj":"GO-BP"},{"subj":"T5","pred":"source","obj":"GO-BP"},{"subj":"T6","pred":"source","obj":"GO-BP"},{"subj":"T7","pred":"source","obj":"GO-BP"},{"subj":"T8","pred":"source","obj":"GO-BP"},{"subj":"T9","pred":"source","obj":"GO-BP"},{"subj":"T10","pred":"source","obj":"GO-BP"},{"subj":"T11","pred":"source","obj":"GO-BP"},{"subj":"T12","pred":"source","obj":"GO-BP"},{"subj":"T13","pred":"source","obj":"GO-BP"},{"subj":"T14","pred":"source","obj":"GO-BP"},{"subj":"T15","pred":"source","obj":"GO-BP"}]},{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":2019,"end":2023},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":2019,"end":2031},"obj":"http://purl.obolibrary.org/obo/GO_0009986"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-CC"},{"subj":"T2","pred":"source","obj":"GO-CC"}]},{"project":"UBERON-AE","denotations":[{"id":"T1","span":{"begin":14,"end":24},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T2","span":{"begin":317,"end":327},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T3","span":{"begin":1950,"end":1960},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T4","span":{"begin":2000,"end":2010},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T5","span":{"begin":888,"end":895},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"T6","span":{"begin":2000,"end":2018},"obj":"http://purl.obolibrary.org/obo/UBERON_0001242"}],"attributes":[{"subj":"T1","pred":"source","obj":"UBERON-AE"},{"subj":"T2","pred":"source","obj":"UBERON-AE"},{"subj":"T3","pred":"source","obj":"UBERON-AE"},{"subj":"T4","pred":"source","obj":"UBERON-AE"},{"subj":"T5","pred":"source","obj":"UBERON-AE"},{"subj":"T6","pred":"source","obj":"UBERON-AE"}]},{"project":"GlycoBiology-MAT","denotations":[{"id":"T1","span":{"begin":14,"end":24},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T2","span":{"begin":140,"end":150},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T3","span":{"begin":317,"end":327},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T4","span":{"begin":370,"end":373},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T5","span":{"begin":779,"end":782},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T6","span":{"begin":834,"end":837},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T7","span":{"begin":888,"end":895},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T8","span":{"begin":1187,"end":1190},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T9","span":{"begin":1224,"end":1227},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T10","span":{"begin":1607,"end":1610},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T11","span":{"begin":1639,"end":1642},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T12","span":{"begin":1694,"end":1697},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T13","span":{"begin":1855,"end":1858},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T14","span":{"begin":1868,"end":1880},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T15","span":{"begin":1912,"end":1915},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T16","span":{"begin":1950,"end":1960},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T17","span":{"begin":1961,"end":1973},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T18","span":{"begin":2000,"end":2010},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T2","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T3","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T4","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T5","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T6","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T7","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T8","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T9","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T10","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T11","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T12","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T13","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T14","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T15","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T16","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T17","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T18","pred":"source","obj":"GlycoBiology-MAT"}]},{"project":"Lectin","denotations":[{"id":"Lectin_T1","span":{"begin":1096,"end":1098},"obj":"https://acgg.asia/db/lfdb/LfDB0227"},{"id":"Lectin_T2","span":{"begin":1301,"end":1303},"obj":"https://acgg.asia/db/lfdb/LfDB0227"},{"id":"Lectin_T3","span":{"begin":1435,"end":1437},"obj":"https://acgg.asia/db/lfdb/LfDB0227"},{"id":"Lectin_T4","span":{"begin":1655,"end":1657},"obj":"https://acgg.asia/db/lfdb/LfDB0227"}],"attributes":[{"subj":"Lectin_T1","pred":"source","obj":"Lectin"},{"subj":"Lectin_T2","pred":"source","obj":"Lectin"},{"subj":"Lectin_T3","pred":"source","obj":"Lectin"},{"subj":"Lectin_T4","pred":"source","obj":"Lectin"}]},{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":14,"end":24},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":140,"end":150},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":317,"end":327},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":1950,"end":1960},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":2000,"end":2010},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":888,"end":895},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":1868,"end":1880},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"PD-UBERON-AE-B_T8","span":{"begin":1961,"end":1973},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"PD-UBERON-AE-B_T9","span":{"begin":2000,"end":2018},"obj":"http://purl.obolibrary.org/obo/UBERON_0001242"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T6","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T7","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T8","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T9","pred":"source","obj":"performance-test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"GlyCosmos6-UBERON","color":"#ebec93","default":true},{"id":"Glycosmos6-MAT","color":"#d393ec"},{"id":"sentences","color":"#93ecb9"},{"id":"GlyCosmos6-CLO","color":"#ec9f93"},{"id":"NCBITAXON","color":"#93a0ec"},{"id":"uniprot-human","color":"#baec93"},{"id":"uniprot-mouse","color":"#ec93d4"},{"id":"GlycoBiology-NCBITAXON","color":"#93ece9"},{"id":"GO-BP","color":"#eccf93"},{"id":"GO-CC","color":"#b593ec"},{"id":"UBERON-AE","color":"#93ec9b"},{"id":"GlycoBiology-MAT","color":"#ec93a4"},{"id":"Lectin","color":"#93beec"},{"id":"performance-test","color":"#d8ec93"}]}]}}