> top > docs > PubMed:1000017

PubMed:1000017 JSONTXT

TIAB (Title and Abstract)
Development of a short term assay for lymphoblastic transformation in man.
Blastic stimulation of lymphocytes by antigens or mitogens is usually measured by 3H-TdR labelling of DNA synthesis in 4 to 7 days. However, it has been recently shown, first in mice and guinea pigs, then in men, that it is possible to detect an earlier event by measurement of protein synthesis with 3H-Leucine in a few hours. The work presented here is devoted to determine the optimal conditions of such a short term assay in man. The technique we propose is described. Preliminary clinical results in lymphomas patients, compared to "in vitro" skin tests, are encouraging.

projects that include this document

Unselected / annnotation Selected / annnotation
PubmedHPO (0)