Different air inlet and outlet combinations including installation of an air curtain were tested to inhibit the spread of virus. Effects of different ventilation geometries were shown on velocity distribution and distribution of bioaerosols in the room. The experimental data collected in the hospital test room correlate with the results of the flow models. The addition of an air curtain leads to less turbulent air flow at the entrance and a decrease in virus particles remaining in the room. Highest phage concentration was detected at the patient’s head, Sampler F. However, the concentration decreased significantly with the air curtain installed. Stronger coronavirus association was measured on plastic and metal surfaces that are commonly used in hospital rooms and frequently touched by patients and healthcare workers, while stronger dissociation was found from the varnished wood surface at 80% relative humidity. Total counts of BCoV were higher at 60% relative humidity compared to 80%.