Subjects
Demographics are presented in Table 1. As expected, CU subjects had higher MMSE scores (i.e. better global cognition) than AD subjects in both TRT (p = 0.003) and longitudinal (p = 0.001) studies. In addition, in the longitudinal study, higher MMSE scores were observed for CU compared with MCI subjects (p = 0.005), as well as a trend towards higher MMSE scores for MCI compared with AD subjects (p = 0.083). There were no differences with respect to age and sex.