FPR2, which has a lower affinity for formylated peptides than FPR1, recognizes diverse ligands2. FPR2 is a specific target receptor for various endogenous molecules, such as antimicrobial peptides (AMPs) and specialized pro-resolving mediators (SPMs)22,26–28. The expression and distribution of FPR2 are quite similar to those of FPR1, from immune cells such as neutrophils to endothelial and epithelial cells2. In the GI tract, FPR2 is expressed on the apical and lateral surfaces of colonic epithelial cells, gastric epithelial cells, and M cells, which are located in Peyer’s patches (PPs)22,29–31. The FPR2 expression level is increased in UC patients compared the healthy controls32.