Cell proliferation was also tested when putative PTEN ceRNAs were depleted, with three comparisons made in each cell line as reported in Figure 4 of this study and Figure 5B of Tay et al., 2011. In wild-type and DicerEx5 HCT116 cells all effects were consistent when considering the direction of the effect and varied in whether the studies were within the confidence interval of the other study (Figure 5D). Additionally, the meta-analyses varied in terms of statistical significance with some meta-analyses having wide confidence intervals and statistically significant Cochran’s Q tests (WT HCT116: siVAPA and siNC, p=0.048; siCNOT6L and siNC, p=2.79×10−4; siPTEN and siNC, p=0.0079; DicerEx5 HCT116: siPTEN and siNC, p=0.029). In DU145 cells, the effects were inconsistent in whether the direction of the effect was the same between the two studies or if the effect size of one study was within the confidence interval of the other study. For all effects, the meta-analysis was not statistically significant, with wide confidence intervals, and statistically significant Cochran’s Q tests (DU145: siVAPA and siNC, p=0.046; siCNOT6L and siNC, p=0.015, siPTEN and siNC, p=0.037), suggesting study heterogeneity.