In vitro dissolution testing is widely used as a predictive biopharmaceutics tool for drug product performance characterisation. Dissolution tests are used for several applications including the following: assessment of batch-to-batch quality process control and quality assurance, formulation development, identification of food effects on the dissolution and bioavailability of orally administered drugs, and of drug solubility limitations and stability issues (22,23). Dissolution tests have been shown to predict in vivo drug behaviour in adults by addressing both medicine administration practices and the physiological gastrointestinal (GI) conditions that can affect drug dissolution (22,24). However, these tests require modifications to assess drug performance in paediatrics. The use of dissolution tests to study the impact of medicine co-administration with vehicles on paediatric drug performance would require the incorporation of age-specific gastrointestinal (GI) tract parameters (namely, pH, media volumes and composition and different dosing scenarios) (25).