Dissolution of mesalazine from Pentasa® and Salofalk® granules also revealed a significant effect of co-administration with food and drink vehicles (Figs. 3 and 4).
Fig. 3 Mean percentage of mesalazine dissolved (± S.D.) from Pentasa® (top panel) and Salofalk® granules (bottom panel) after direct administration of formulation, after mixing with selected vehicles (full lines) and with vehicles of the same subtype (dashed lines). Dotted vertical lines represent the time of medium change
Fig. 4 Effect of co-administration of formulation with vehicles on percentage of drug dissolved at 4 h from the tested formulations. Asterisk symbol denotes a statistical difference on drug dissolution between direct administration (dashed line) and co-administration with vehicles (bars; red: drinks, blue: soft foods). a denotes statistical difference when vehicles of the same subtype were tested (p < 0.05)