For the direct administration scenario, the formulations were introduced in the media without being mixed with a vehicle. For the scenario of mixing the formulations with vehicles, each sample was prepared by addition of the formulations (corresponding to the ‘dose tested’ in Table I) to 25 mL of drink or 10 mL (approximately 10 g) of soft food, at room temperature. All samples were then manually mixed with a stainless-steel spatula, for 30 s. Actavis® chewable tablets were crushed prior to being mixed with the vehicles or tested.