Figure 7 c shows the cumulative percentage of drug permeated against time. Table VIII shows that at the 10th hour, only 58% of the drug was permeated to the releasing media. The drug permeation profile had been prolonged due to the smaller porosity and thicker intestinal membrane compared with the dialysis membrane. The surface area of the intestine accommodating formulation was 5 cm2.15 Pappcms−1=1.1626mg10×60×60s×15cm2×1mg/cm3=6.4589×10−6cms−116 Jssmgcm−2s−1=6.4589×10−6cms−1×1mg/cm3=6.4589×10−6mgcm−2s−1
Table 8 Amount, Percentage of Acyclovir Permeated, and Apparent Permeability at Each Time Point
t Amount permeated % permeated Apparent permeability (mg/cm2)
0 0.0000 ± 0.0000 00.00 ± 0.00 0.0000 ± 0.0000
0.5 0.5902 ± 0.0009 29.51 ± 0.05 0.1180 ± 0.0002
1 0.8525 ± 0.0003 42.63 ± 0.01 0.1705 ± 0.0001
2 1.0565 ± 0.0010 52.83 ± 0.05 0.2113 ± 0.0002
4 1.0806 ± 0.0003 54.03 ± 0.01 0.2161 ± 0.0001
6 1.0937 ± 0.0001 54.69 ± 0.00 0.2187 ± 0.0000
8 1.1074 ± 0.0002 55.37 ± 0.01 0.2215 ± 0.0000
10 1.1626 ± 0.0016 58.13 ± 0.08 0.2325 ± 0.0003