Stability Study
A replicate of optimised PALN was prepared without lyophilisation and assessed for short-term physical stability for 60 days based on ICH guidelines. The sample was stored in 4°C chiller throughout the study period. Nanoparticle size of the sample was measured by using the method as described in section F at an interval of 0th, 15th, 30th, 45th, and 60th days. A p < 0.05 was considered as significant for the obtained data.