The linear trapezoidal method was used to calculate the area under the curve of each in vitro % drug dissolved over 4-h profile (AUC0–4 h in vitro). One-way analysis of variance (ANOVA) with a post hoc Tukey honest significant difference (HSD) test was conducted to investigate differences in the AUC0–4 h in vitro calculated from the dissolution studies, after direct administration of formulation and after mixing the formulation with the different vehicles (p < 0.05 noting significance level). T test analysis was used to compare experimental results under fasted-state gastric conditions, followed by fasted- or fed-state intestinal conditions (represented as Pi-FaSSGF/FASSIF-V2 and Pi-FaSSGF/Pi-FeSSIF, respectively) (significance p < 0.05). Analyses were performed with GraphPad Prism® v.7 software (USA).