Non-progressive group (n = 7) Progressive group (n = 20) Between group comparison (p) Hospital admission and follow-up comparison (p)
Parameter At hospital admission Follow-up At hospital admission Follow-up
AST*
 Increased (n, %) 19 (10–28)
0 (0) 17 (12–20)
0 (0) 18 (7–51)
2 (10) 22 (5–97)
5 (25) 0.825a 0.071b 0.149c 0.141d
ALT*
 Increased (n, %) 18 (5–58)
2 (28.6) 19 (6–50)
1 (14.3) 16 (6–50)
1 (5) 29 (9–127)
5 (25) 0.471a 0.030b 0.344c 0.020d
ALP
 Increased (n, %) 61 (39–109)
1 (14.3) 60 (39–248)
1 (14.3) 60 (36–98)
0 (0) 55.5 (30–124)
1 (5) 0.725 0.246
GGT
 Increased (n, %) 20.5 (11–39)
1 (14.3) 21 (7–63)
2 (28.6) 17.5 (7–81)
2 (10) 24 (10–177)
6 (30) 0.950 0.148
Total bilirubin
 Increased (n,%) 0.2 (0.1–0.4)
0 (0) 0.3 (0.1–0.4)
0 (0) 0.3 (0.01–1.3)
1 (5) 0.4 (0.2–1.2)
2 (10) 0.063 0.006
Creatinine*
 Increased (n, %) 0.7 (0.4–0.9)
0 (0) 0.8 (0.4–1)
0 (0) 0.8 (0.1–3.7)
2 (10) 0.7 (0.5–2.7)
1 (5) 0.234a 0.009b 0.027c 0.098d
Urea
 Increased (n, %) 29 (14–33)
0 (0) 25 (13–34)
0 (0) 30 (12–235)
2 (10) 27 (16–221)
2 (10) 0.376 0.035
CRP*
 Increased (n, %) 4.4 (0.3–135.6)
3 (42.8) 0.8 (0.3–211)
1 (14.3) 12.6 (0.5–310.9)
14 (70) 37.7 (1–176)
18 (90) 0.439a 0.105b 0.249c 0.039d
LDH
 Increased (n, %) 194 (132–384)
2 (28.6) 182 (166–376)
3 (42.8) 204 (138–300)
5 (25) 211 (117–364)
7 (35) 0.949 0.700
D-dimer
 Increased (n, %) 275 (169–1355)
2 (28.6) 248 (168–1413)
3 (42.8) 647.5 (169–1919)
11 (55) 643.5 (169–2733)
8 (40) 0.114 0.856
WBC
 Increased (n, %)
 Decreased (n,%) 8.3 (4.3- 13.9)
1 (14.3)
1 (14.3) 8.5 (5.1–13.2)
1 (14.3)
0 (0) 4.9 (0.6–8.9)
0 (0)
7 (35) 5.1 (0.5–12.1)
1 (5)
6 (30) 0.000e 0.088
Neutrophil
 Increased (n, %)
 Decreased (n,%) 4.7 (2–7.6)
1 (14.3)
0 (0) 5.3 (2.4–10.3)
1 (14.3)
0 (0) 3 (0.4–6.7)
0 (0)
5 (25) 3.3 (0.3–9.7)
1 (5)
3 (15) 0.037e 0.208
Lymphocyte
 Increased (n, %)
 Decreased (n,%) 2.4 (1.3–4.7)
2 (28.6)
0 (0) 2.3 (1.5–3.6)
0 (0)
0 (0) 1.4 (0.08–2.1)
0 (0)
6 (30) (0.1–2)
0 (0)
4 (20) 0.000e 0.777
Monocyte
 Increased (n, %) 0.9 (0.3–1.3)
4 (57.1) 0.8 (0.4–1)
2 (28.6) 0.5 (0.1–0.9)
2 (10) 0.5 (0.07–1)
2 (10) 0.009e 0.731
NLR 1.6 (0.8–5) 2 (0.9–6.1) 2.2 (1–4.8) 2.7 (0.9–14.9) 0.267 0.299
Hb
 Decreased (n,%) 11.3 (8.2–16.2)
3 (42.8) 11.5 (7.4–16.1)
3 (42.8) 13.3 (1.9–17)
3 (15) 12.7 (4.5–16.4)
3 (15) 0.475 0.050
Platelet
 Increased (n, %)
 Decreased (n,%) 253 (203–399)
0 (0)
0 (0) 285 (191–409)
0 (0)
0 (0) 190 (68–247)
0 (0)
2 (10) 219 (86–336)
0 (0)
2 (10) 0.000e 0.084