SARS-CoV-2 infects target cells through the interaction of the viral spike (S) protein with cell receptors. This is an essentially dynamic event that is hard to analyze using most structural biology techniques. However, cryo-EM offers some unique capabilities that makes it a very suitable approach for this task, especially the facts that it can work with noncrystalline samples and, to a certain degree, those with structural flexibility (Dashti et al., 2014 ▸; Maji et al., 2020 ▸; Scheres et al., 2007 ▸; Sorzano et al., 2019 ▸; Tagare et al., 2015 ▸).