After the proposed process, excess stabilizer and free drug would remain in the spray-dried powder. The spray-dried powder could be directly used for further downstream processing (e.g., tableting) into a final dosage form for applications where free drug and stabilizer are not an issue. Alternatively, the dry powder intermediate may be purified before further processing. Centrifuge purification works well for PVA and is well established at lab scale, but the scalability is limited and particles may deform or agglomerate under stress (9). Continuous purification methods, such as cross-flow filtration, are preferred at larger scale, but are challenging for formulations containing PVA: Residual amounts of PVA were found to be several times higher after filtration than after centrifugation (21,22). P-407 has been previously shown to work well with the double emulsion solvent displacement method and is easily removed by crossflow filtration (9). Therefore, we evaluated the potential of using P-407 with the double emulsion spray drying method.