Drug Loading Evaluation and Dissolution Study Ibuprofen sodium drug loading was evaluated for each formulation. Results showed that ibuprofen sodium loading in film F5 was 6.82% w/v ± 0.01 and 7.01% w/v ± 0.01 in film F6. Drug loading was expected to be 10% w/v, and F5 and F6 saw ~ 69% drug loading efficacy. The lower than anticipated drug content is expected when no stabilizing agents are added to a formulation (46). The in vitro dissolution profile of ibuprofen sodium was analyzed in PBS pH 6.8 to mimic buccal conditions and compared with the release profile of the drug from the film formulation. The dissolution rate percentage was calculated according to assessed drug loading and related to film weight. Data showed a slower dissolution rate with ibuprofen sodium alone compared to dissolution rate when incorporated within the film. In each profile, it was observed that drug in its crystalline state achieved a condition of supersaturation due to the solubilizing effect of polymer combination (47,48). The dissolution profile of ibuprofen sodium showed a drug release of 59% at 15 min, while F5 had a drug release of 74%, a 1.25-fold increase (p = 0.002), and F6 of 72%, a 1.22-fold increase (p < 0.0001), resulting in an immediate-like release. This data indicates that the dissolution rate was faster when the drug was incorporated into films compared to medication alone. The calculation of data also confirmed area under curve (AUC) which was increment from 7093 ± 179 μg/h/mL for ibuprofen sodium to 7922 ± 443.8 μg/h/mL (F5) and 8296 ± 185.1 μg/h/mL (F6). Moreover, data showed that lower concentration of PVA increases release profile as confirmed from previous literature findings (44). As the difference between two PVA concentrations is 1.02-fold difference, it is considered the possibility that an increase in drug dissolution profile is due to the addition of PHEA itself.