Drug solid-state morphology is an essential parameter to evaluate to understand the dissolution profile. DSC analyzed thermal properties of drug and polymers, and thermograph of PVA showed an endothermic peak at 192°C recognized to be the melting point of polymer which is present in crystalline form. This finding relates to the literature (39), while PHEA was amorphous and no peak is visible at DSC. Ibuprofen sodium showed a sharp peak at 101°C (Δcp 10.89 J/g), confirmed by existing literature, which indicates that it is present in its crystalline form (31).